Abstract
Objectives: To compare clonidine with tramadol for shivering control following spinal anesthesia.
Methods: The literature was searched updated to August 2020, and only randomized controlled trials comparing clonidine and tramadol for shivering control following spinal anesthesia were eligible for this study.
Results: Fourteen studies with 960 patients were identified. Clonidine demonstrated a lower effective rate of shivering control (OR: 0.59; 95% CI: 0.40-0.88; p=0.009; I2=36%), but with decreased occurrence of nausea, vomiting, and dizziness. Clonidine increased the occurrence of bradycardia, hypotension, and sedation compared to tramadol.
Conclusion: Tramadol is more effective for shivering control than clonidine, but with increased occurrence of nausea, vomiting, and dizziness.
PROSPERO No: CRD42020207979
Footnotes
Disclosure. Authors have no conflict of interests, and the work was not supported or funded by any drug company.
- Received October 7, 2020.
- Accepted January 26, 2021.
- Copyright: © Saudi Medical Journal
This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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