Fatal butane toxicity and delayed onset of refractory ventricular fibrillation
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* Khalid N. Almulhim

## Abstract

A 30-year-old male was presented to the Emergency Department (ED) by the Emergency Medical Services (EMS). He was found unconscious but breathing normally, and had a seizure for more than 30 minutes. He was no previous history of systemic disease, previous operation, medication and any known allergy. According to the witnesses, he was alone in the coffee shop, and besides him was a lighter refill canister containing 250 ml extra purified butane gas, and he suddenly collapsed and had seizure. Six hours later, he developed ventricular fibrillation and he was not responding to amiodarone infusion, and 4 times defibrillation and cardioversion. He died after 45 minutes of resuscitation.

Toxicity of any substance is the degree at which it creates harmful effect on human being or any organism. Usually toxicity will be of 2 types, acute toxicity and chronic toxicity, where the former inflicts harmful effects immediately at a single exposure, or a short-term exposure to the toxin, but the later become detrimental with an extended period of time with intermittent or long term exposure of the toxin by the patient. Butane is a colorless, highly inflammable organic compound, which is in a gaseous state at normal atmospheric pressure and at room temperature. Butane is usually used in fuel gas, as a component of petroleum and for many different industrial purposes. It is also used as a fuel for the common cigarette lighters and is available in canisters for refill. Butane in lighters will be with small quantities of isobutane and propane, which is commercially available in the market. Different types of butane abuse or accidental inhalations are reported to the emergency units of hospitals, which is becoming a serious public health issue. Sen et al1 discussed the misuse of the volatile agent, the cause of intoxication, and the management of such a case in the intensive care units. Acute exposure guideline levels (AEGL) for selected airborne chemicals2 expressed in parts per million, defines 3 AEGLs with varying degree of severity and toxic effects. Of the 3 AEGLs, the third AEGL could lead to life-threatening health issues or even death. The AEGL explains the cases specifying that butane might cause arrhythmias in humans exposed at high concentrations, and no adequate human or animal data are available to evaluate its end point in a quantitative way. The guideline also pointed out similar case reports, which indicate that single exposure to high concentrations of butane might cause severe brain damage in fetus, but no adequate data are available for a quantitative evaluation in humans. However, there is an old study conducted in human volunteers indicates that a patient who is exposed to butane illustrates cutaneous lesions, which may be secondary to absorption of the toxic product, probably induced by inhalation rather than by percutaneous penetration.3 Because of its easy access, often it is used in higher dose for inhalant abuse. Even though the toxicity of butane is low, the period and frequency of exposure to the substance is also a deciding factor. Sasao et al4 reported 3 forensic autopsy cases of sudden death that occurred while sniffing n-butane and isobutane from portable gas cartridges and they concluded in their study that the presence or absence of n-butane metabolites might reflect the way of butane inhalation, such as the frequency and duration. Hence, how many times and how long the case is exposed to butane is an important predicting factor, which makes the situation serious enough for a fatal incident. This case report is discussing the case, describing the symptoms, signs, diagnosis, and treatment of an unusual case of a 30-year-old male with delayed onset of refractory ventricular fibrillation.

## Case Report

A 30-year-old male was presented to the Emergency Department (ED) by the Emergency Medical Services (EMS) and he was unconscious when he was bought to the ED and he has been on seizure for more than 30 minutes. He was unconscious and was breathing normally when the EMS arrived at him. It was reported that the patient was without any history of systemic disease, previous surgeries, medication and any known allergy. According to the witnesses, the patient was alone in a coffee shop and besides him was a lighter refill canister containing 250 ml extra purified butane gas, and reported that he suddenly collapsed and had seizure. Started infusion of fluids, but tachycardia persists despite the infusion of 2 liters of fluids. He was then intubated for securing the airway and introduced mechanical ventilation with volume-control (FiO2: 0.50, Tidal volume: 550 ml, frequency: 12 beats/min, positive end-expiratory pressure: 5 cm H2O) and the central line was inserted. He was also sedated with midazolam and fentanyl infusion.

### Clinical findings

Upon presentation, the following were the observations made by the ED physicians: heart rate: 170 beats per minute, body temperature: 37.8°, oxygen saturation: 90% on room air temperature, electrocardiogram: sinus tachycardia (**Figure 1**), and **Table 1** illustrates the timeline of the case, starting from the time of spotting to admission until the final outcome with diagnosis of condition and different stages of interventions.

![Figure 1](http://smj.org.sa/https://smj.org.sa/content/smj/38/12/1250/F1.medium.gif)

[Figure 1](http://smj.org.sa/content/38/12/1250/F1)

Figure 1 
Electro cardiogram of patient demonstrating sinus tachycardia.

View this table:
[Table 1](http://smj.org.sa/content/38/12/1250/T1)

Table 1 
Timeline of a 30-year-old male presented with delayed onset of refractive ventricular fibrillation following butane inhalation.

### Diagnostic assessment

Laboratory investigation indicates acute renal failure, high levels of creatinine kinase (1700 U/L), indication of tissue damage, especially myocardium and muscle tissue. Computed tomography of the brain shows mild brain edema.

### Follow-up and outcome

Tachycardia persisted even after 3 hours later, followed by dropping of blood pressure to 70/50 mm Hg. Hence, the physician started infusing intropes, but 6 hours later he developed ventricular fibrillation. He did not respond to amiodarone infusion, followed by 4 times of defibrillation and cardioversion. Finally, he died after 45 minutes of resuscitation.

## Discussion

We presented with a case of delayed onset of refractive ventricular fibrillation (VF) following butane inhalation. Butane refill canisters are popular among the people, especially among the youth due to the easy availability, which contains hydrocarbons.5 Based on the available literature, the refill canister contains 54% n-butane, 26% propane, and 20% isobutane. Ago et al6 reported that n-butane in the can of anti-perspiration aerosol deodorant induced fatal cardiac arrhythmia, which leads to the death of patient. Sugie et al,7 with autopsy findings and gas analysis reveals that the cause of death in their case was ventricular fibrillation, induced by hard muscle exercise in few minutes after gas inhalation. But in our case, VF sets in after a long gap, which was in contradiction to the other reported literatures. However, few studies indicated delayed fatalities with multiple organ failures.8 Williams et al9 reported a successful resuscitation case followed by a volatile substance abuse and according to them this was the first documented evidence of VF associated with butane gas, which illustrates the tragedy of butane abuse even in fit young people. Sen et al10 also reported butane intoxication, where the patient had a syncope and persistent VF during the course of resuscitation. Myocardial infarction (MI) in children is a very rare condition, but as reported by Godlewski et al11 butane inhalation to the toxic level can even lead to sudden cardiac arrest due to VF even in children. Another study conducted by Gunn et al12 also illustrated that butane sniffing cause ventricular fibrillation. But, in our case, we were not sure how long and how much the patient was exposed to butane at the time he was found unconscious.

Inhalation of butane, the extremely volatile hydrocarbon when enters the lung replaces oxygen, which leads to hypoxia and the patient slowly become unconscious. Butane, the highly lipophylic gas reaches the brain and lungs, while propane affects the central nervous system, which once enters the circulation gets concentrated in these organs. Moreover, butane acts as a catecholamine, leading to a fatal condition of tachyarrhythmias, which was clear from the ECG findings. The hydrocarbon, butane usually causes inflammation of the walls of alveoli,13 but the x-ray findings was without any signs of lung inflammation or pneumonitis. The toxicological property of butane seriously affects the brain, resulting in subsequent development of severe brain damage.14 However, there was no serious damage in the brain, which was clarified from the CT findings, indicating only mild brain edema. But, the high level of creatinine kinase was an indicator of muscle tissue damage.15

Furthermore, cardiac involvement of butane toxicity is common and is reported in the available literature that it may be due to coronary artery spasms. El-Menyar et al16 assumes in their study that cardiac complications after butane inhalations may partly be secondary to intense coronary artery spasm on the basis of clinical and laboratory findings. The cardiac involvement also leads to frequent ventricular fibrillations, which makes resuscitation difficult. Edwards et al17 suggest that antiarrhythmic agents should be used early during resuscitation to prevent recurrent arrhythmias. However, infusion of infusing intropes did not work out in this case and developed ventricular fibrillation, resulting in the death of patient. The available literature also illustrates that a massive intoxication of butane leads to serious damages, which includes VF resulting in sudden death. This is demonstrated by Zivković et al,18 where they concluded that propane-butane mixture leads to the depletion of oxygen in the air, consequently causing hypoxia and anoxia, which leads to unconsciousness and eventual death. They also mentioned that the causes of death include cardiac arrhythmias, reflex cardiac vagal inhibition, and/or central nervous system depression. Another study by Bowen et al19 stated that deaths associated with the abuse of butane and toluene, where all substances appeared to be capable of killing directly by their toxic effects, probably through cardiac and/or respiratory mechanisms. However, a case report made by Wien Klin Wochenschr et al8 explained the case of a 14 year old boy who inhaled butane gas from an aerosol-can used for refilling gas lighter. In this case the boy died 2 days later due to multiple organ failure involving the central nervous system, cardiovascular system, pulmonary system, and liver. Nevertheless, there are not much study indicating a delayed onset of refractory VF and its association with butane toxicity the relation.

In conclusion, delayed onset of VF may be because of a low level of toxicity from butane inhalation. Hence, management of such cases will be difficult to handle unless and until the right information is received by the physician. We recommend the emergency management system to collect as much as information, right from the source immediately after transferring the patient to the intensive care units.

Case Reports

Case reports will only be considered for unusual topics that add something new to the literature. All Case Reports should include at least one figure. Written informed consent for publication must accompany any photograph in which the subject can be identified. Figures should be submitted with a 300 dpi resolution when submitting electronically. The abstract should be unstructured, and the introductory section should always include the objective and reason why the author is presenting this particular case. References should be up to date, preferably not exceeding 15.

## Footnotes

*   **Disclosure.** Authors have no conflict of interests, and the work was not supported or funded by any drug company.

*   Received July 10, 2017.
*   Accepted July 18, 2017.


*   Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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