PT  - JOURNAL ARTICLE
AU  - Abdulaziz Alqahtani
TI  - Bacteriophage treatment as an alternative therapy for multidrug-resistant bacteria
AID  - 10.15537/smj.2023.44.12.20230366
DP  - 2023 Dec 01
TA  - Saudi Medical Journal
PG  - 1222--1231
VI  - 44
IP  - 12
4099  - http://smj.org.sa/content/44/12/1222.short
4100  - http://smj.org.sa/content/44/12/1222.full
SO  - Saudi Med J2023 Dec 01; 44
AB  - Multidrug-resistant (MDR) bacteria constitute one of the most serious global health threats. The increasing incidence rate of bacterial infections caused by MDR strains and the decrease in the number of newly developed antibiotics have prompted the scientific community to search for alternatives. One such alternative is the use of bacteriophages. In this review, we discuss the most critical MDR organisms, including Acinetobacter baumanni, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus. The efficacy of phage therapy against MDR bacteria is also discussed. We included studies from the last 10 years that examined the efficacy of phage therapy against MDR pathogens. In addition, this review highlights the effect of bacteriophages against bacterial biofilms. The existing knowledge indicates that phage therapy is a potential therapeutic strategy against MDR bacteria. However, the adverse effects of phage therapy, such as toxicity, and the emergence of phage resistance have not yet been resolved.