PT  - JOURNAL ARTICLE
AU  - Rana M. Hasanato
TI  - Diagnostic efficacy of random albumin creatinine ratio for detection of micro and macro-albuminuria in type 2 diabetes mellitus
AID  - 10.15537/smj.2016.3.13567
DP  - 2016 Mar 01
TA  - Saudi Medical Journal
PG  - 268--273
VI  - 37
IP  - 3
4099  - http://smj.org.sa/content/37/3/268.short
4100  - http://smj.org.sa/content/37/3/268.full
SO  - Saudi Med J2016 Mar 01; 37
AB  - Objectives: To compare a less cumbersome random albumin creatinine ratio (RACR) with 24-hour urinary albumin excretion (UAE) for detection of renal damage in patients with type 2 diabetes mellitus (T2DM).Methods: This retrospective study performed between March 2013 and June 2014 at the Department of Pathology, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia included 122 patients (mean age 54±15, 104 females and 18 males) with T2DM. Urine albumin levels of <30 mg/g was considered normal, from 30-300 mg/g considered as micro-albuminuria, and over 300 mg/g considered as macro-albuminuria.Results: Concordance between the 2 assays was observed in 114 (93.4%) samples. The sensitivity of RACR assay was 100%, specificity was 91.3% with a positive predictive value (PPV) of 95%, and a negative predictive value (NPV) of 100% in micro-albuminuria range. For macro-albuminuria, RACR had a sensitivity of 100%, specificity of 94.1% with PPV of 94% and NPV of 100%. Receiver operating characteristic (ROC) curves analysis cut-off values of 40 mg/g-300 mg/g for micro- and >300 mg/g for macro-albuminuria revealed 100% sensitivity, 97.5% specificity, 95% PPV, and 100% NPV for micro-albuminuria, and 100% sensitivity, 94% specificity, 76% PPV, and 100% NPP for macro-albuminuria. The area under the curve for micro-albuminuria was 100% and 98.2% for macro-albuminuria.Conclusion: Performance of RACR was comparable to 24 hour UAE assay particularly in excluding renal damage in T2DM.