PT  - JOURNAL ARTICLE
AU  - Alghamdi, Hanan M.
AU  - Amr, Samir S.
AU  - Shawarby, Mohamed A.
AU  - Sheikh, Salwa S.
AU  - Alsayyah, Ahmed A.
AU  - Alamri, Ali M.
AU  - Ismail, Mona H.
AU  - Almarhabi, Ahmed
AU  - Alrefaee, Munir A.
AU  - Ahmed, Muhammad I.
TI  - Gastrointestinal stromal tumors
AID  - 10.15537/smj.2019.2.23913
DP  - 2019 Feb 01
TA  - Saudi Medical Journal
PG  - 126--130
VI  - 40
IP  - 2
4099  - http://smj.org.sa/content/40/2/126.short
4100  - http://smj.org.sa/content/40/2/126.full
SO  - Saudi Med J2019 Feb 01; 40
AB  - Objectives: To evaluate the clinical presentations and immunohistochemical (IHC) properties of gastrointestinal stromal tumors (GISTs) and to compare them to internationally published data.Methods: Thirty-six patients diagnosed with GISTs between January 1997 and December 2015 were retrospectively studied in 2 tertiary hospitals. Immunohistochemical staining was carried out prospectively when it has not been completed fully at the beginning.Results: The median age of patients was 54 years (range; 17-81 years). Predominantly, we found more females were affected. The male to female ratio was 1:1.7. The most frequently affected organs were the stomach (63.8%) followed by small bowel (25%) and colorectal region (8.4%). Abdominal pain was the most frequent presentation in 33.3% of the patients then gastrointestinal (GI) bleeding in 30.5%. Most of the gastric GISTs were at early stages at presentation: stage 1 and II (60.8%), while in non-gastric GISTs, the tumor stage was advanced: stage III and IV (69.3%). The IHC characteristic of GIST in descending order showed positivity for vimentin (88.9%), CD117 (83.3%), CD34 (77.8%), Ki67 (63.9%), SMA (38.9%), desmin (27.8%), and S100 (19.4%).Conclusion: Gastrointestinal stromal tumors in our study demonstrates a major similar feature as the published international data. However, minor differences do exist in terms of clinical features and immunohistochemistry.