- Association of rs1143627 in the interleukin-1 beta (IL-1β) gene with different autoimmune diseases in populations of different ancestries.
| Ref. | Disease | No. (patients/controls) | Associated genotype or allele | OR (95% CI) | P-value | Frequency (patient vs. control) | Ethnicity |
|---|---|---|---|---|---|---|---|
| [23] | Primary Sjögren syndrome (pSS) | 101/106 | TT | 0.59 (0.31–1.13) | 0.027 | 19.6 vs. 29.2 | Japanese |
| [24] | Rheumatoid arthritis | 180/249 | TT | 1.21 (0.92–1.61) | 0.01 | 0.26 vs. 0.15 | Indian |
| [25] | Systemic lupus erythematosus | 50/25 | TT | 8.27 (1.53–44.61) | <0.01 | 26 vs. 8 | Egyptian |
| [26] | Alzheimer’s disease | 123/120 | TT | 1.72 (1.13–2.61) | 0.010 | 51 (41.5) vs. 31 (25.8) | Chinese |
| [27] | Immune thrombocytopenia | 118/100 | TT | 2.33 (1.069–5.09) | 0.033 | 25.43 vs. 19 | Indian |
| CT | 2.044 (1.068–39) | 0.034 | 55.08 vs. 47 | ||||
| T | 1.52 (1.04–2.22) | 0.034 | 52.69 vs. 42.5 | ||||
| [28] | Systemic sclerosis | 78/692 | TC | 2.7 (1.5–5.1) | 0.002 | 62.0 vs. 43.8 | Caucasian |
| [29] | Systemic lupus erythematosus | 163/180 | CC | 0.6 (0.4–0.9) | <0.01 | 52 (32) vs. 81 (45) | Iranian |
| CC | 0.7 (0.5–0.9) | 191 (58.6) vs. 247 (68.6) | |||||
| [30] | Coronary artery lesions in Kawasaki disease | 719/1401 | AA | 2.28 (1.32–3.95) | 0.003 | 50 vs. 29 | Chinese |
CI: confidence interval, OR: odd ratio,l vs: versus, ref: reference, no.: number