Cellular functions of long noncoding RNAs

RW Yao, Y Wang, LL Chen - Nature cell biology, 2019 - nature.com
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

[PDF][PDF] Coordinated circRNA biogenesis and function with NF90/NF110 in viral infection

…, W Xue, Y Zhang, S Jiang, QF Yin, J Wei, RW Yao… - Molecular cell, 2017 - cell.com
Circular RNAs (circRNAs) generated via back-splicing are enhanced by flanking complementary
sequences. Expression levels of circRNAs vary under different conditions, suggesting …

[HTML][HTML] Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection

S Wu, J Xu, L Zou, S Luo, R Yao, B Zheng… - Nature …, 2021 - nature.com
Peri-implant infection is one of the biggest threats to the success of dental implant. Existing
coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult …

[PDF][PDF] Dynamic imaging of RNA in living cells by CRISPR-Cas13 systems

LZ Yang, Y Wang, SQ Li, RW Yao, PF Luan, H Wu… - Molecular cell, 2019 - cell.com
Visualizing the location and dynamics of RNAs in live cells is key to understanding their
function. Here, we identify two endonuclease-deficient, single-component programmable RNA-…

[PDF][PDF] SLERT regulates DDX21 rings associated with Pol I transcription

YH Xing, RW Yao, Y Zhang, CJ Guo, S Jiang, G Xu… - Cell, 2017 - cell.com
Dysregulated rRNA synthesis by RNA polymerase I (Pol I) is associated with uncontrolled
cell proliferation. Here, we report a box H/ACA small nucleolar RNA (snoRNA)-ended long …

[PDF][PDF] Nascent pre-rRNA sorting via phase separation drives the assembly of dense fibrillar components in the human nucleolus

RW Yao, G Xu, Y Wang, L Shan, PF Luan, Y Wang… - Molecular cell, 2019 - cell.com
Fibrillar centers (FCs) and dense fibrillar components (DFCs) are essential morphologically
distinct sub-regions of mammalian cell nucleoli for rDNA transcription and pre-rRNA …

[HTML][HTML] Image segmentation based on adaptive K-means algorithm

X Zheng, Q Lei, R Yao, Y Gong, Q Yin - EURASIP Journal on Image and …, 2018 - Springer
Image segmentation is an important preprocessing operation in image recognition and
computer vision. This paper proposes an adaptive K-means image segmentation method, which …

Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria

Y Wang, SB Hu, MR Wang, RW Yao, D Wu, L Yang… - Nature cell …, 2018 - nature.com
The long noncoding RNA NEAT1 (nuclear enriched abundant transcript 1) nucleates the
formation of paraspeckles, which constitute a type of nuclear body with multiple roles in gene …

[PDF][PDF] Unusual processing generates SPA LncRNAs that sequester multiple RNA binding proteins

H Wu, QF Yin, Z Luo, RW Yao, CC Zheng, J Zhang… - Molecular cell, 2016 - cell.com
We identify a type of polycistronic transcript-derived long noncoding RNAs (lncRNAs) that
are 5′ small nucleolar RNA (snoRNA) capped and 3′ polyadenylated (SPAs). SPA …

Convalescent plasma to treat COVID-19: Chinese strategy and experiences

S Pei, X Yuan, Z Zhang, R Yao, Y Xie, M Shen, B Li… - medRxiv, 2020 - medrxiv.org
The COVID-19 is currently spreading around the world, which has posed significant threats
to global health and economy. Convalescent plasma is confirmed effective against the novel …