Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …

BACKGROUND: The coronavirus disease 2019 pandemic continues to affect millions worldwide.
Given the rapidly growing evidence base, we implemented a living guideline model to …

Given the rapidly changing nature of COVID-19, clinicians and policy makers require urgent
review and summary of the literature, and synthesis of evidence-based guidelines to inform …

… ; Alshamsi, Fayez 14 ; Angus, Derek C. ; Arabi, Yaseen 16 ; Azevedo, Luciano 17 ; Beale,
Richard 18 ; Beilman, Gregory 19 ; Belley-Cote, Emilie 20 ; Burry, Lisa 21 ; Cecconi, Maurizio …

Background: Fluid resuscitation is the cornerstone of sepsis treatment. However, whether
balanced or unbalanced crystalloids or natural or synthetic colloids confer a survival …

Background Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV)
and is characterized by hypoxemic respiratory failure. The objective of this study is to …

Conventional gabaminergic sedatives such as benzodiazepines and propofol are commonly
used in mechanically ventilated patients in the intensive care unit (ICU). Dexmedetomidine …

Background Atraumatic needles have been proposed to lower complication rates after
lumbar puncture. However, several surveys indicate that clinical adoption of these needles …

Background Intolerance to enteral nutrition is common in critically ill adults, and may result
in significant morbidity including ileus, abdominal distension, vomiting and potential …