[HTML][HTML] Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression

…, N Reina, M Karanian, LR Le Nail… - Nature …, 2019 - nature.com
Chondrosarcomas are primary cancers of cartilaginous tissue with highly contrasting
prognoses. These tumors are defined by recurrent mutations in the IDH genes and other genetic …

[HTML][HTML] Effect of decalcification protocols on immunohistochemistry and molecular analyses of bone samples

…, M Tallegas, B Brulin, LR Le Nail, A Tallet, F Le Loarer… - Modern Pathology, 2020 - Elsevier
Diagnosis of osteocartilaginous pathologies depends on morphological examination and
immunohistochemical and molecular biology analyses. Decalcification is required before …

[HTML][HTML] H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach

…, B Marie, E Miquelestorena-Standley, LR Le Nail… - Modern Pathology, 2017 - Elsevier
Behjati et al recently described recurrent mutations of H3F3 genes in giant cell tumors of the
bone and chondroblastomas. Both these entities belong to the spectrum of giant cell-rich …

Are spine metastasis survival scoring systems outdated and do they underestimate life expectancy? Caution in surgical recommendation guidance

…, LM Terrier, A Dubory, J Cristini, LR Le Nail… - … of Neurosurgery: Spine, 2021 - thejns.org
OBJECTIVE Survival scoring systems for spine metastasis (SPM) were designed to help
surgical practice. The authors sought to validate the prognostic accuracy of the main …

Percutaneous grafting with bone marrow autologous concentrate for open tibia fractures: analysis of forty three cases and literature review

LR Le Nail, J Stanovici, J Fournier, M Splingard… - International …, 2014 - Springer
Purpose Tibial fractures are the most common lower limb fractures. Some criteria such as
open fractures and increasing open stage are known to be associated with high delayed union …

Acetabular reconstruction with an ice‐cream cone prosthesis following resection of pelvic tumors: Does computer navigation improve surgical outcome?

…, M Parry, Y Tsuda, LR Le Nail… - Journal of surgical …, 2020 - Wiley Online Library
Background and Objectives Acetabular reconstruction with a coned‐stem prosthesis has
been one of the reliable procedures following pelvic tumor resections but is associated with a …

[HTML][HTML] Bone microenvironment has an influence on the histological response of osteosarcoma to chemotherapy: retrospective analysis and preclinical modeling

…, C Dumars, R Guiho, L Vidal, LR Le Nail… - American journal of …, 2017 - ncbi.nlm.nih.gov
Osteosarcoma, the most common malignant primary bone tumor, is currently treated with
chemotherapy and surgery. The effectiveness of chemotherapy is evaluated by means of …

[HTML][HTML] Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

…, J Brossaud, H Dakik, B Roux, S Hamard, LR Le Nail… - Oncogene, 2020 - nature.com
The bone marrow (BM) niche impacts the progression of acute myeloid leukemia (AML) by
favoring the chemoresistance of AML cells. Intimate interactions between leukemic cells and …

[HTML][HTML] Impact of preoperative varus on ankle replacement survival

M Boble, LR Le Nail, J Brilhault - Orthopaedics & Traumatology: Surgery & …, 2022 - Elsevier
Introduction The severity of a foot or ankle deformity is a major prognostic factor for the
success of ankle replacement. Varus deformity is at once the most arthrogenic and the most …

[HTML][HTML] Determinants of the access to remote specialised services provided by national sarcoma reference centres

Y Fayet, R Tétreau, C Honoré, LR Le Nail, C Dalban… - BMC cancer, 2021 - Springer
Background Spatial inequalities in cancer management have been evidenced by studies
reporting lower quality of care or/and lower survival for patients living in remote or socially …