Objectives: To estimate age at menarche and to assess trends in menarcheal age among
Saudi women. Methods: A prospective longitudinal study was conducted among healthy …

Background Studies of the effect of highly active antiretroviral therapy (HAART) on the risk of
HIV-1-associated tuberculosis have had variable results. We set out to determine the effect …

Background Data from Kwazulu Natal, South Africa, suggest that almost all patients with
extensively drug-resistant (XDR) tuberculosis are HIV-positive, with a fatal outcome. Since, there …

Background Long-term treatment-related outcomes in patients with extensively drug-resistant
(XDR) tuberculosis are unknown. We followed up a cohort of patients to address …

Background To assess the prevalence and risk factors for faecal carriage of fluoroquinolone-resistant,
extended-spectrum β-lactamase (ESBL)-producing, Escherichia coli (MDR E. coli) …

Rationale: The optimal strategy for the diagnosis of latent tuberculosis infection is controversial.
Adoption of a two-step strategy (tuberculin skin test [TST] followed by an IFN-γ release …

Background The accurate diagnosis of TB in HIV-infected patients, particularly with advanced
immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) …

Background In sub-Saharan Africa, data for short-term risk of AIDS or death, which might
inform decisions about when to start antiretroviral therapy (ART), are scarce. Our aim was to …

Background Little information exists on the impact of highly active antiretroviral therapy (HAART)
on health-care provision in South Africa despite increasing scale-up of access to …

Background Long-term immunosuppression is often required in myasthenia gravis (MG).
There are no published trials using methotrexate (MTX) in MG. The steroid-sparing efficacy of …