Background Alternative therapies for Staphylococcus aureus bacteremia and endocarditis
are needed. Methods We randomly assigned 124 patients with S. aureus bacteremia with or …

These guidelines were formulated to assist physicians and other health care professionals
with various aspects of the administration of outpatient parenteral antimicrobial therapy (OPAT…

Peripherally inserted central catheters (PICCs) have become popular for long courses of
intravenously administration of antibiotics. Although these devices are generally regarded as …

The evolution of methicillin-resistant and vancomycin-resistant Staphylococcus aureus has
demanded serious review of antimicrobial use and development of new agents and revised …

Objectives In a prospective, randomized trial, daptomycin was non-inferior to standard
therapy for Staphylococcus aureus bacteraemia and right-sided endocarditis. Since rates of …

Objectives Laboratory tests are usually requested for monitoring during outpatient parenteral
antimicrobial therapy (OPAT), but these recommendations are not always followed. The …

This is the fourth in a series of practice guidelines commissioned by the Infectious Diseases
Society of America through its Practice Guidelines Committee. The purpose of this guideline …

Objectives The need for indwelling vascular access for outpatient parenteral antimicrobial
therapy (OPAT) places patients at risk of vascular access complications. The purpose of this …

Background Testing excised valves in surgically treated infective endocarditis (IE) patients
provides an opportunity to identify the microbial etiology of IE. Microbial sequencing (…

Prolonged hospitalization for therapy of some infections may be economically and emotionally
costly to patients. A multidisciplinary team was organized at the Cleveland Clinic Hospital …