User profiles for Xiaonan Guan

Xiaonan Guan

Postdoc @ Columbia University
Verified email at cumc.columbia.edu
Cited by 68

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

J Qian, X Guan, B Xie, C Xu, J Niu, X Tang… - Science Translational …, 2023 - science.org
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function
heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome in …

[HTML][HTML] Using nutritional strategies to shape the gastro-intestinal tracts of suckling and weaned piglets

AMS Huting, A Middelkoop, X Guan, F Molist - Animals, 2021 - mdpi.com
Simple Summary Throughout the world, piglet mortality and morbidity in large litters are a
major welfare concern and source of economic losses. Gastro-intestinal problems rank …

[HTML][HTML] Hippocampal cells segregate positive and negative engrams

M Shpokayte, O McKissick, X Guan, B Yuan… - Communications …, 2022 - nature.com
The hippocampus is involved in processing a variety of mnemonic computations specifically
the spatiotemporal components and emotional dimensions of contextual memory. Recent …

Construction of an efficient microalgal-fungal co-cultivation system for swine wastewater treatment: Nutrients removal and extracellular polymeric substances (EPS) …

Q Wu, S Li, H Wang, W Wang, X Gao, X Guan… - Chemical Engineering …, 2023 - Elsevier
Microalgal-fungal co-cultivation technology has demonstrated outstanding efficacy in
wastewater treatment and valuable resources recovery. However, it is still unclear how …

RETRACTED: Bone marrow mesenchymal stem cells-derived exosomal microRNA-185 represses ventricular remolding of mice with myocardial infarction by …

Y Li, J Zhou, O Zhang, X Wu, X Guan, Y Xue, S Li… - 2020 - Elsevier
Concern was raised about the integrity of the images in Figures 5B and 7C, which appear to
contain suspected duplications, as detailed here: https://pubpeer. com/publications/…

Constructal design for the layout of multi-chip module based on thermal-flow-stress coupling calculation

G Nan, Z Xie, X Guan, X Ji, D Lin - Microelectronics Reliability, 2021 - Elsevier
The thermal-flow-stress coupling model of multi-chip module with uniform heat generation
under natural convection condition is established. Taking the chip aspect ratio and edge …

[HTML][HTML] Environmental and maternal factors shaping tonsillar microbiota development in piglets

S Fredriksen, X Guan, J Boekhorst, F Molist… - BMC microbiology, 2022 - Springer
Background The palatine tonsils are part of the mucosal immune system and stimulate immune
responses through M cell uptake sampling of antigens and bacteria in the tonsillar crypts. …

[HTML][HTML] Optimization of fin layout in liquid-cooled microchannels for multi-core chips

J Zhang, W Guo, Z Xie, X Guan, X Qu, Y Ge - Case Studies in Thermal …, 2023 - Elsevier
When the dense pin-fins array distributed uniformly is used to dissipate the non-uniform
heat source, it is easy to generate excessive cooling at the non-hot spot, which leads to …

miR‐202‐5p protects rat against myocardial ischemia reperfusion injury by downregulating the expression of Trpv2 to attenuate the Ca 2+ overload in …

Y Li, Q Li, O Zhang, X Guan, Y Xue, S Li… - Journal of Cellular …, 2019 - Wiley Online Library
Background This study was aimed to unveil micro RNA (miRNA) expression profiles in
myocardial ischemia‐reperfusion (MI/R) rats and explore whether and how dysregulated miRNAs …

[HTML][HTML] Effect of Resin Acid and Zinc Oxide on Immune Status of Weaned Piglets Challenged With E. coli Lipopolysaccharide

X Guan, RR Santos, H Kettunen… - Frontiers in Veterinary …, 2021 - frontiersin.org
With the ban of zinc oxide (ZnO) at high dosages in piglet diets in Europe by 2022, alternative
nutritional solutions are being tested to support piglet immune defence during their …