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Research ArticleOriginal Article
Open Access

A comparative study of the ultrastructure of submandibular, parotid and exocrine pancreas in diabetes and fasting

Gulnur Take, Celal Ilgaz, Deniz Erdogan, Candan Ozogul and Cigdem Elmas
Saudi Medical Journal January 2007, 28 (1) 28-35;
Gulnur Take
Associate and Research Fellow, Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (312) 2024614 / +90 532 3859300. Fax. +90 (312) 2124647. E-mail: [email protected]
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Celal Ilgaz
Department of Histology and Embryology, School of Medicine, Gazi University, Ankara, Turkey.
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Deniz Erdogan
Department of Histology and Embryology, School of Medicine, Gazi University, Ankara, Turkey.
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Candan Ozogul
Department of Histology and Embryology, School of Medicine, Gazi University, Ankara, Turkey.
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Cigdem Elmas
Department of Histology and Embryology, School of Medicine, Gazi University, Ankara, Turkey.
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Abstract

OBJECTIVE: To comparatively analyze the ultrastructural changes in the submandibular and parotid glands and in the exocrine pancreas following diabetes induced by Streptozotocin exposure and the effects of fasting and insulin treatment on these alterations.

METHODS: For experimental procedure, we included 48 Sprague-Dawley type rats in July 2001-March 2002 at Gazi University, Turkey. We divided the rats into 8 groups following the infusion of Streptozotocin.

RESULTS: While the degeneration manifested itself as accumulation of secretions within the mucous cells in the submandibular gland, lipid droplets were absent, being replaced by vacuolar structures. The parotid gland and exocrine pancreas, having similar properties, were affected similarly. Diabetes-induced loss of granules was observed in the serous cells in both glands. There was diffuse lipid accumulation within these cells. Regarding granule content, we observed the most prominent degenerative changes in the parotid gland. While cellular loss was observed in neither the submandibular, nor the parotid gland, we noted presence of apoptotic cells was noted in the pancreas. State of fasting was found to cause alterations within the glands indicating increased activity. While insulin treatment was seen to restore the structure to normal in general in both of the 3 glands.

CONCLUSION: This study demonstrated that both of the 3 glands are affected by diabetes and concomitant fasting, and this effect manifests itself via the granule content.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 28 (1)
Saudi Medical Journal
Vol. 28, Issue 1
1 Jan 2007
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A comparative study of the ultrastructure of submandibular, parotid and exocrine pancreas in diabetes and fasting
Gulnur Take, Celal Ilgaz, Deniz Erdogan, Candan Ozogul, Cigdem Elmas
Saudi Medical Journal Jan 2007, 28 (1) 28-35;

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A comparative study of the ultrastructure of submandibular, parotid and exocrine pancreas in diabetes and fasting
Gulnur Take, Celal Ilgaz, Deniz Erdogan, Candan Ozogul, Cigdem Elmas
Saudi Medical Journal Jan 2007, 28 (1) 28-35;
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© 2022 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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