Endobronchial valve therapy for patients with advanced emphysema. A report from a tertiary care center in China

Objectives: To assess the efficiency and safety of endobronchial valve (EBV) treatment in Chinese patients. Methods: A retrospective analysis was performed in patients with chronic obstructive pulmonary disease who underwent EBV implantation in our hospital between October 2010 and January 2017. All patients were confirmed with no collateral ventilation (CV-) or with low airflow (LF) in the treated lobe. Pulmonary function parameters, the 6-minute walk distance (6MWD), the modified Medical Research Council (mMRC), as well as adverse events in the follow-up period were recorded. Results: Thirty-eight advanced emphysema patients received EBV implantation. Significant improvements were found in forced expiratory volume in 1 second (FEV1)(FEV1: +0.12 L), 6MWD (+64.9 m), and mMRC (-0.5 points). A total of 55.3% and 65.8% of subjects met the score for the minimal clinically important difference in FEV1 and 6MWD, respectively. FEV1 improved more significantly in the CV- group than in the LF group. Pneumothorax or death did not occur during the follow-up period. Conclusion: Endobronchial valve treatment in patients with advanced emphysema and CV- provides clinically meaningful benefits with a low incidence of pneumothorax. The efficiency and safety of EBV therapy are acceptable in China.

C hronic obstructive pulmonary disease (COPD) is defined as a severe, long-standing respiratory disease characterized by persistent limitation of airflow and worsening disease course. 1 Chronic obstructive pulmonary disease causes persistent and progressive respiratory symptoms and therefore leads to breathing difficulties.Medication alone has shown inadequate efficacy in patients with severe COPD and advanced emphysema. 2Since 2003, endobronchial valves (EBV) has emerged as a potential therapeutic alternative for advanced emphysema.Recent randomized controlled trials on EBV (TRANSFORM 2017, LIBERATE 2018) had shown that patients without collateral ventilation (CV-) of the targeted lobe could benefit significantly. 3,4owever, the proportion of patients who achieved or exceeded the minimal clinically important difference (MCID) in FEV 1 was still unsatisfactory (only 49.9%-59.3%).Therefore, further exploration of a better patient selection criterion for EBV therapy is required.
In China, EBV was first used for patients with advanced emphysema in 2010 in our hospital.In this study, we aimed to present our experience of EBV therapy in terms of its safety and efficacy and to investigate the pre-procedure predictors in Chinese patients.
Methods.This retrospective analysis was carried out among patients with advanced emphysema treated with EBV (Pulmonx, Inc., Redwood City, CA, USA) in our hospital in China between October 2010 and January 2017.Patients eligible for this study were those diagnosed with severe COPD and advanced emphysema.A Chartis assessment (Pulmonx, Inc., Redwood City, CA, USA) was performed on all patients in the same bronchoscopic operation before EBV treatment, and targeted lobes were confirmed to have no CV or low airflow.The other inclusion and exclusion criteria were as follows: i) aged between 40 to 75; ii) heterogeneous emphysema; iii) FEV 1 of less than 45% of the predicted value, total lung capacity (TLC) of >100% of the predicted value, and residual volume (RV) of >150 percent of the predicted value; iv) body mass index of <31.1 kg/m 2 (male) or 32.3 kg/m 2 (female); v) PaCO 2 of <75 mmHg and PaO 2 of more than 45 mmHg (while breathing ambient air); vi) 6MWD of at least 100 m.In addition, acute exacerbation of COPD and other severe pulmonary diseases, thoracic surgery, sputum production >4 tablespoons per day, pulmonary hypertension (≥40 mmHg), fever or any other sign of an active infection, psychosis or any diseases that might fail the assessments were excluded.
Registry.A written informed consent was obtain from all subjects to participate in this study.
Computed tomography (CT) scans (SOMATOM Definition; Siemens Healthcare, Forchheim, Germany) were performed at the breathing level of TLC at baseline and post-procedure.Quantitative CT analyses were performed at baseline and follow-up scans, using a Food and Drug Administration-approved imaging software (FACT® quantitative software, De Xin, Shaanxi, China).Two radiologists independently handled the semi-automatic analyses of all scans.The fissure integrity (FI) of each lobe was also calculated automatically and assessed by an experienced radiologist.The integrity of the interlobar fissure was defined as a calculation of more than 90% of the fissure areas by the FACT® software.
Clinical and radiological outcomes were evaluated.The assessment of clinical outcomes was performed by the pulmonary function test, the 6MWD, and the modified Medical Research Council (mMRC) dyspnea scale.The improvements in FEV 1 , forced vital capacity, TLC, RV, 6MWD, and the mMRC dyspnea scale were analyzed from baseline to post-procedure.A clinical response was defined when FEV 1 or 6MWD achieved the MCID from the baseline (FEV 1 , a 15% increase; 6MWD, a 25 m increase), and the clinical response rate was calculated.All adverse events were noted during the study.
Statistical analysis.The SPSS for Windows, version 26.0 (IBM Corp., Armonk, N.Y., USA) was used for data analysis.Continuous variables were shown as mean ± SD or median (interquartile range) whenever appropriate.The outcome variables at baseline and postprocedure were compared by Wilcoxon signed-rank test or Paired t-test.The number of patients who had achieved the MCID score for FEV 1 or 6MWD was used to calculate response rates.The results were considered statistically significant when p-value of <0.05.
Results.From 2010 to 2017, 38 patients with advanced emphysema received EBV implantation in our hospital.Before EBV therapy, optimal medical management (including COPD medication, continuous oxygen, and pulmonary rehabilitation for at least 3 months) was prescribed.The average post-bronchodilator FEV 1 , 6MWD, and mMRC scores at baseline were 0.85 ± 0.28 L, 287.06 ± 98.54 m, and 3.0 points.The interval between baseline assessments and the treatment was 11 days [6, 14 days].Other baseline demographics and characteristics are shown in Table 1.
Under general anesthesia (28.9%) or conscious sedation (71.1%), a median of 3 valves (range, 1-6) were inserted into the bronchi of the targeted lobe for each subject.Five patients received EBV treatment in the right middle lobe alone.In addition, 71.1% of the treated lobes had no CV and 28.9% had a low flow (LF), according to the Chartis System results.Finally, 65.8% of the treated lobes had >90% FI and 34.2% of the treated lobes had <90% FI (80% -90% FI: 5 patients; <80% FI: 8 patients).
Clinical outcomes.The interval from treatment to follow-up assessment was 86 days [78, 97 days].At 3 months post-procedure, a significant improvement was noted in FEV 1 with an absolute change of 0.12 ± 0.20 L (p<0.001).Meanwhile, forced vital capacity, EBV for treating advanced emphysema... Yu et al Disclosure.This study was supported by a grant (82070040) from the National Natural Science Foundation of China (General Program).The AUC values of the combination strategy and the Chartis system were greater than that of the CT fissure analysis (p<0.05).However, the difference between the combination strategy and the Chartis System was not statistically significant (p>0.05).
Adverse events.During the 3-month follow-up period, there were no deaths.Table 3 summarized all adverse events occurred.The most common adverse events were coughing, increase in sputum production, and chest discomfort.Most of these presentations were mild or moderate and could be relieved by symptomatic treatment.Pneumothorax did not occur in any of the subjects.Seven serious adverse events occurred in 6 (15.8%) subjects.Three (7.9%) experienced a COPD exacerbation during the treatment period.All of these patients achieved remission after hospitalization.One patient coughed up one valve 2 months after EBV treatment and received a valve reimplantation.Pneumonia in a non-treated lobe occurred in one patient, and hiatus hernia occurred in another patient.Both of them were relieved after medication.
Eight patients received one revision bronchoscopy at the 3-month follow-up visit because of coughing or increased sputum production.Granulation tissue formation was found in 5 patients, 4 of which (80%) did not meet or exceed the MCID in FEV 1 .Valve replacement was performed in 2 patients for valve migration.One patient had the valves permanently removed due to personal request.
Discussion.Endobronchial valves therapy has become one of the treatment options for patients with advanced emphysema.Our study showed that EBV therapy provided clinically meaningful improvements in exercise tolerance, lung function, and dyspnea in EBV for treating advanced emphysema... Yu et al Chinese patients with advanced emphysema and no CV, with a low incidence of pneumothorax.
A statistically significant improvement in FEV 1 was observed in patients with no CV.The absence of CV was generally considered as the key point for treatment success of EBV.However, in 2016, Herzog et al 5 described the 4 Chartis phenotypes that were found in COPD patients: CV positive (CV+); CV-; LF and low plateau.Significant improvements in both FEV 1 and target lung volume reduction were seen in both CV-and LF patients with an ipsilateral CV-lobe.Theoretically, the LF phenotype is considered to be attributed to a phenomenon called the "dynamic collapse", and the effects of EBV on this type of patient remain unclear. 6,7n our study, only 20% of the subjects with LF achieved the MCID for FEV 1 , which means that the LF patient may not be considered as a potential candidate for EBV therapy.
In this study, the diagnostic performance of the Chartis system was superior to that of the CT fissure analysis.The combination strategy only caused a slight improvement in the predictor accuracy, however, some patients did lose some benefit from this method.Direct measurement of CV by the Chartis System was preferred for patient selection.Meanwhile, CV was an independent predictor for clinical benefit.Gompelmann et al 8 reported similar accuracy for predicting TLVR using EBV between the Chartis system and HRCT (74% vs 77%).de Oliveira et al 9 and Koster et al 10 suggested 2 new combination criteria for patient selection.The latest expert panel recommendation is as follows: For patients with FI >95%, Chartis measurement is optional; for patients with 80-95% completeness of the fissure, Chartis measurement is recommended; for patients with FI <80%, EBV therapy is not suitable and Chartis evaluation is not needed. 11However, according to a recent study, Chartis assessment should always be taken in the right lung, even with a complete fissure (>95%). 12In general, more studies on the evaluation of the Chartis system and HRCT are needed for achieving a greater clinical benefit in a larger patient population.
Notably, pneumothorax did not occur postprocedure, which was different from that reported in recent randomized clinical trials showing a pneumothorax rate of 29.2-34.4%.The average percentage of emphysematous destruction in the ipsilateral lobe was only 27.7%, which was significantly lower than that found in previous studies.The incidence of pneumothorax might be increased by a worse ipsilateral lobe.Meanwhile, the smaller average TLVR in the LF group may have led to a total lower incidence of pneumothorax.It also might depend on the heterogeneity of lungs.In our study, all subjects had the heterogeneous emphysema (heterogeneity: 25.7% [15.3%, 34.6%]).Unfortunately, we did not find the correlation between degree of heterogeneity and the incidence of pneumothorax.It might be limited by the small sample size of the study cohort.Our results may be clinically meaningful, as pneumothorax is the most important post-procedural complication.A better ipsilateral lobe may be an effective way to reduce the rate of pneumothorax, which also needs to be confirmed in further research.
Study limitation.First, this was a retrospective post-hoc analysis, even though EBV therapy was performed in accordance with the predetermined standardized strategies.Second, there was no assessment of quality of life due to the lack of data from the St. George's Respiratory Questionnaire.Third, the follow-up period was only 3 months.Finally, the small sample size of the study cohort inevitably limited the statistical significance of the results.To confirm this study's findings, additional prospective studies with a longer follow-up period are required.
In conclusion, patients with advanced emphysema and no collateral ventilation could benefit significantly from endobronchial valve therapy with a low incidence of pneumothorax.More studies are needed to further increase the proportion of patients who could achieve significant clinical benefits from EBV treatment.

Table 2 -
Clinical changes of subjects prior to and 3 months after EBV implantation.

Table 3 -
Adverse events occurred during 3 months after endobronchial valve treatment.Lu and Dr. Hu Shaohui in the Pulmonary Function Examination Room for providing the pulmonary function test results of patients.We would like to thank Medjaden (https://en.medjaden.com/)for English language editing.Received 17th July 2022.Accepted 20 October 2022.From the Senior Department of Respiratory and Critical Care Medicine, the Eighth Medical Center, Chinese PLA General Hospital, Beijing, China.Address correspondence and reprints request to: Dr. Liang-an Chen, Senior Department of Respiratory and Critical Care Medicine, the Eighth Medical Center, Chinese PLA General Hospital, Beijing, China.E-mail: Chenla301@263.netORCID ID: https://orcid.org/0000-0002-1829-3134