An unusual cause of elevated serum total βhCG

CL Buckner, L Wilson… - Annals of Clinical & …, 2007 - Assoc Clin Scientists
Human chorionic gonadotropin (hCG), a heterodimeric hormone consisting of an alpha (α)
and a beta (β) subunit, is used as a marker for the diagnosis of pregnancy, congenital …

Are laboratories reporting serum quantitative hCG results correctly?

Z Cao, R Rej - Clinical chemistry, 2008 - academic.oup.com
Background: Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone
that exists in multiple forms. Immunoassays commonly used in clinical laboratories measure …

False-positive hCG assay results leading to unnecessary surgery and chemotherapy and needless occurrences of diabetes and coma

LA Cole, KM Rinne, S Shahabi, A Omrani - Clinical chemistry, 1999 - academic.oup.com
Much concern has been raised by the unraveling at the hCG Reference Service of six cases
of persistent phantom human chorionic gonadotropin (hCG). These are false-positive hCG …

Falsely decreased human chorionic gonadotropin (hCG) results due to increased concentrations of the free β subunit and the β core fragment in quantitative hCG …

DG Grenache, DN Greene, AS Dighe… - Clinical …, 2010 - academic.oup.com
BACKGROUND Earlier studies have shown that increased concentrations of certain human
chorionic gonadotropin (hCG) variants can cause false-negative results in some qualitative …

Utility of commonly used commercial human chorionic gonadotropin immunoassays in the diagnosis and management of trophoblastic diseases

LA Cole, S Shahabi, SA Butler, H Mitchell… - Clinical …, 2001 - academic.oup.com
Background: Patients with trophoblastic diseases produce ordinary and irregular forms of
human chorionic gonadotropin (hCG; eg, nicked hCG, hCG missing the β-subunit C-terminal …

Method evaluation for total β-human chorionic gonadotropin using urine and the ADVIA centaur

AM Halldorsdottir, MO Carayannopoulos… - Clinical …, 2003 - academic.oup.com
We recently described the use of a quantitative serum human chorionic gonadotropin (hCG)
assay with urine samples (1). Quantitative urine hCG assays are important in validations of …

Human chorionic gonadotropin and associated molecules

LA Cole - Expert review of molecular diagnostics, 2009 - Taylor & Francis
When considering human chorionic gonadotropin (hCG) and hCG tests, it is important to
realize that it is not a single biological molecule. The regular form of hCG produced by …

Determination of human chorionic gonadotropin

UH Stenman, H Alfthan - Best Practice & Research Clinical Endocrinology & …, 2013 - Elsevier
Determination of human chorionic gonadotropin (hCG) is used for diagnosis and monitoring
of pregnancy, pregnancy related disorders, for trophoblastic and some nontrophoblastic …

Discordant results in human chorionic gonadotropin assays

LA Cole, A Kardana - Clinical Chemistry, 1992 - academic.oup.com
Discordance has been reported in human chorionic gonadotropin (hCG) concentrations
measured by different immunoassay kits. We examined the results for 40 serum samples …

Heterophile antibody blocking agent to confirm false positive serum human chorionic gonadotropin assay

N Esfandiari, JM Goldberg - Obstetrics & Gynecology, 2003 - journals.lww.com
BACKGROUND Persistently false positive human chorionic gonadotropin (hCG) test results
in the absence of an intrauterine pregnancy may lead to a diagnosis of ectopic pregnancy or …