Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …

Neural signalling within the central nervous system (CNS) requires a highly controlled
microenvironment. Cells at three key interfaces form barriers between the blood and the …

Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …

The contribution of tumorigenic stem cells to haematopoietic cancers has been established
for some time, and cells possessing stem-cell properties have been described in several …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

Nanoparticles (NPs) have emerged as an effective modality for the treatment of various
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …

Root‐secreted chemicals mediate multi‐partite interactions in the rhizosphere, where plant
roots continually respond to and alter their immediate environment. Increasing evidence …

Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only
nutritionally important but serve as precursors for ligands that bind to receptors in the …

Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad
spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in …