PT  - JOURNAL ARTICLE
AU  - Hu, Yan-Yan
AU  - Li, Gui-Mei
AU  - Wang, Wei
TI  - Euthyroid sick syndrome in children with diabetic ketoacidosis
AID  - 10.15537/smj.2015.2.10304
DP  - 2015 Jan 01
TA  - Saudi Medical Journal
PG  - 243--247
VI  - 36
IP  - 2
4099  - http://smj.org.sa/content/36/2/243.short
4100  - http://smj.org.sa/content/36/2/243.full
SO  - Saudi Med J2015 Jan 01; 36
AB  - Objectives: To investigate characteristics of euthyroid sick syndrome (ESS) in children with diabetic ketoacidosis (DKA).Methods: This retrospective study was carried out between May 2010 and April 2013 at the Pediatric Department of Shandong Provincial Hospital, Shandong University, Shandong, China. Diabetic ketoacidosis children were divided into 2 groups: euthyroidism (group one, n=30) and ESS (group 2, n=40). C-peptide, glycosylated hemoglobin (HbA1c), bicarbonate, anion gap (AG), free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) levels were measured before and after 7 days of insulin treatment. Daily blood glucose (BG) profiles were recorded.Results: Glycosylated hemoglobin, AG, the mean daily BG, and fasting blood glucose levels were higher, and bicarbonate, FT3, FT4, and TSH levels were lower in group 2 than in group one (all p<0.05). Free triiodothyronine (r=-0.593, p<0.001) and FT4 (r=-0.402, p=0.001) were negatively correlated with HbA1c. Free triiodothyronine (r=-0.438, p<0.001) and FT4 (r=-0.505, p<0.001) were negatively correlated with AG, and FT3 (r=0.503, p<0.001) and FT4 (r=0.448, p<0.001) were positively correlated with bicarbonate.Conclusion: Diabetic ketoacidosis children with ESS have poor diabetic control. Free thyroid hormones are associated with the severity of DKA.