PT  - JOURNAL ARTICLE
AU  - Al-Ammar, Ahmed Y.
TI  - Effect of use of mitomycin C on the outcome of Choanal atresia repair.
DP  - 2007 Oct 01
TA  - Saudi Medical Journal
PG  - 1537--1540
VI  - 28
IP  - 10
4099  - http://smj.org.sa/content/28/10/1537.short
4100  - http://smj.org.sa/content/28/10/1537.full
SO  - Saudi Med J2007 Oct 01; 28
AB  - OBJECTIVES: To investigate the effectiveness of topical mitomycin C (MMC) on outcome of endoscopic repair of choanal atresia (CA) in cases that had never had this operation and when nasal stent was not used.METHODS: Endoscopic repair of CA was performed in 20 children at King Abdul-Aziz University Hospital, Riyadh, Kingdom of Saudi Arabia between January 1999 and October 2005. Intra-operative application of topical MMC (0.4 mg/mL for 4 minutes) was carried out in 13 children, and 7 children did not receive MMC. The follow-up period ranged between 9 months and 6 years. The association between the 2 categorical variables was investigated using Fisher's exact test.RESULTS: Sixty-nine percent of the cases receiving MMC had a successful outcome compared with 57% of non-MMC cases, however, the difference was not statistically significant (p=0.230). In unilateral CA, 70% of those who received MMC had a successful outcome compared with 60% of those who did not; again the difference was not statistically significant (p=0.566). Successful outcome was considered when the posterior choana was patent during the successive follow up, without the need for revision surgeries.CONCLUSIONS: We did not demonstrate a statistically significant difference between the percentages of children treated with MMC versus no-MMC who remained patent after surgery.