PT  - JOURNAL ARTICLE
AU  - Obasi, Obasi E.
AU  - Osoba, Abimbola O.
AU  - Raddadi, Ali A.
TI  - Ecthyma gangrenosum in Saudi Arabia
DP  - 2007 Nov 01
TA  - Saudi Medical Journal
PG  - 1741--1744
VI  - 28
IP  - 11
4099  - http://smj.org.sa/content/28/11/1741.short
4100  - http://smj.org.sa/content/28/11/1741.full
SO  - Saudi Med J2007 Nov 01; 28
AB  - We report a diagnosis of ecthyma gangrenosum EG in 4 females of mean age 54.8 range 43-64 years, within 10 months. Severe drug reaction treated with high dose systemic corticosteroids in patient one, acute myelocytic leukemia treated with high dose dexamethasone, and multiple broad-spectrum antibiotics in patient 2 preceded the onset of EG. Patients 3 and 4 had vasculitic purpura and hemodialysis. In addition, patient 3 was receiving multiple broad-spectrum antibiotics plus anti-tuberculosis TB drugs for gastric TB, while patient 4 was on melphalan and high dose systemic corticosteroids. Pseudomonas aeruginosa was isolated from blood culture of the first 3 patients, and skin culture of patient one. Blister aspirate from patient 4 yielded Candida albicans. Factors enhancing skin invasion by pathogenic organisms in our patients were breached skin integrity, therapy with high dose corticosteroids and multiple broad-spectrum antibiotics, hematologic malignancies and chemotherapy with severe neutropenia.