RT Journal Article
SR Electronic
T1 Osteoarthritis models after anterior cruciate ligament resection and medial meniscectomy in rats. A histological and immunohistochemical study
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1796
OP 1802
VO 28
IS 12
A1 Piskin, Ahmet
A1 Gulbahar, Mustafa Y.
A1 Tomak, Yilmaz
A1 Gulman, Birol
A1 Hokelek, Murat
A1 Kerimoglu, Servet
A1 Koksal, Bulent
A1 Alic, Taner
A1 Kabak, Yonca B.
YR 2007
UL http://smj.org.sa/content/28/12/1796.abstract
AB OBJECTIVE: To compare the amount of degeneration based on the time spent, using 2 different methods of surgically induced osteoarthritis (OA) that frequently used in treating OA.METHODS: We undertook this research in Ondokuz Mayis University, Surgical Research Center between April 2006 and July 2006. In this study, 55 rats were used, 7 as the control group, and 12 in each of 4 groups. We compared the amount of OA formed by the medial meniscectomy (MMx) and anterior cruciate ligament transection (ACLT) at 8 and 16 weeks according to the Modified Mankin Score and histologically and immunohistochemically due to their response to Matrix metalloproteinase 13 expression (MMP13).RESULTS: We observed the highest degeneration in the MMx model at 8 weeks, and this situation continued until 16 weeks. However, the degeneration in the ACLT model was lower at 8 weeks compared with the MMx group, however, it reached the same amount as the MMX group at 16 weeks.CONCLUSION: The OA model formed by the ACLT method was better than the MMx model when degeneration and time were taken into consideration and should be used when researching drugs on an experimental basis in OA.