PT  - JOURNAL ARTICLE
AU  - Ding, Hua-Sheng
AU  - Yang, Jun
TI  - High mobility group box-1 and cardiovascular diseases
DP  - 2010 May 01
TA  - Saudi Medical Journal
PG  - 486--489
VI  - 31
IP  - 5
4099  - http://smj.org.sa/content/31/5/486.short
4100  - http://smj.org.sa/content/31/5/486.full
SO  - Saudi Med J2010 May 01; 31
AB  - High mobility group box-1 (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of almost all cells. After binding to its receptor, HMGB1, which is derived from necrotic cells and activated macrophages/monocytes, functions as a critical mediator of inflammation and promotes tissue repair and regeneration. Many recent studies demonstrated that HMGB1 played a pivotal role in cardiovascular diseases, such as atherosclerosis, myocardial ischemia/reperfusion injury, heart failure, and myocardial infarction. In this review, we focus on HMGB1 and summarize the association of HMGB1 with cardiovascular diseases.