PT - JOURNAL ARTICLE AU - Hua-Sheng Ding AU - Jun Yang TI - High mobility group box-1 and cardiovascular diseases DP - 2010 May 01 TA - Saudi Medical Journal PG - 486--489 VI - 31 IP - 5 4099 - http://smj.org.sa/content/31/5/486.short 4100 - http://smj.org.sa/content/31/5/486.full SO - Saudi Med J2010 May 01; 31 AB - High mobility group box-1 (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of almost all cells. After binding to its receptor, HMGB1, which is derived from necrotic cells and activated macrophages/monocytes, functions as a critical mediator of inflammation and promotes tissue repair and regeneration. Many recent studies demonstrated that HMGB1 played a pivotal role in cardiovascular diseases, such as atherosclerosis, myocardial ischemia/reperfusion injury, heart failure, and myocardial infarction. In this review, we focus on HMGB1 and summarize the association of HMGB1 with cardiovascular diseases.