TY - JOUR T1 - High mobility group box-1 and cardiovascular diseases JF - Saudi Medical Journal JO - Saudi Med J SP - 486 LP - 489 VL - 31 IS - 5 AU - Hua-Sheng Ding AU - Jun Yang Y1 - 2010/05/01 UR - http://smj.org.sa/content/31/5/486.abstract N2 - High mobility group box-1 (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of almost all cells. After binding to its receptor, HMGB1, which is derived from necrotic cells and activated macrophages/monocytes, functions as a critical mediator of inflammation and promotes tissue repair and regeneration. Many recent studies demonstrated that HMGB1 played a pivotal role in cardiovascular diseases, such as atherosclerosis, myocardial ischemia/reperfusion injury, heart failure, and myocardial infarction. In this review, we focus on HMGB1 and summarize the association of HMGB1 with cardiovascular diseases. ER -