PT  - JOURNAL ARTICLE
AU  - Raihan Sajid
AU  - Bushra Moiz
AU  - Natasha Ali
AU  - Nausheen Kamran
AU  - Adil N. Adil
AU  - Usman Shaikh
AU  - Mohammad Khurshid
TI  - Therapeutic outcomes of older patients with acute myeloid leukemia
DP  - 2010 May 01
TA  - Saudi Medical Journal
PG  - 533--538
VI  - 31
IP  - 5
4099  - http://smj.org.sa/content/31/5/533.short
4100  - http://smj.org.sa/content/31/5/533.full
SO  - Saudi Med J2010 May 01; 31
AB  - OBJECTIVE: To evaluate the therapeutic outcomes of acute myeloid leukemia (AML) in elderly patients.METHODS: This study was conducted at the Aga Khan University Hospital, Karachi, Pakistan over 11 years from January 1997 to August 2008. This was a descriptive case series study. We investigated the impact of disease biology and various treatment protocols on the outcome in this population.RESULTS: A total of 55 evaluable patients (>60 years of age) were diagnosed with AML including 34 (61.8%) males and 21 (38.2%) females. The median age was 67 years (range 60-86 years) at the time of presentation. The AML was preceded by myelodysplastic syndrome in 15 (27.2%) patients. High-risk cytogenetics were observed in 3 (5.4%) patients. Forty patients received palliative treatment while only 15 received chemotherapy. Of the last group with primary AML (n=10), there were 2 remitters, one showed resistant disease while 8 had induction death. The overall mean survival was 75.1 days (95% confidence interval: 46.7-103.5 days) in all patients. There was no survival advantage in patients treated with chemotherapy versus those conservatively treated.CONCLUSION: We found high mortality among aged patients with AML in our setting. Patients receiving chemotherapy were extremely intolerant to toxic drugs and succumbed earlier than patients receiving palliative care only.