PT  - JOURNAL ARTICLE
AU  - Hongfang Lu
AU  - Jingang Wang
AU  - Baoan Gao
AU  - Shixiong Chen
AU  - Guangming Xiang
AU  - Shaojuan Yang
AU  - Yuan Gong
AU  - Li Guan
TI  - The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility
AID  - 10.15537/smj.2015.12.12264
DP  - 2015 Dec 01
TA  - Saudi Medical Journal
PG  - 1400--1407
VI  - 36
IP  - 12
4099  - http://smj.org.sa/content/36/12/1400.short
4100  - http://smj.org.sa/content/36/12/1400.full
SO  - Saudi Med J2015 Dec 01; 36
AB  - Objectives: To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk.Methods: PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated.Results: Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p=0.000 for mutant homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p=0.000 for GG versus CC in the Arab descent.Conclusion: Our findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB.