PT - JOURNAL ARTICLE AU - Lu, Hongfang AU - Wang, Jingang AU - Gao, Baoan AU - Chen, Shixiong AU - Xiang, Guangming AU - Yang, Shaojuan AU - Gong, Yuan AU - Guan, Li TI - The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility AID - 10.15537/smj.2015.12.12264 DP - 2015 Dec 01 TA - Saudi Medical Journal PG - 1400--1407 VI - 36 IP - 12 4099 - http://smj.org.sa/content/36/12/1400.short 4100 - http://smj.org.sa/content/36/12/1400.full SO - Saudi Med J2015 Dec 01; 36 AB - Objectives: To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk.Methods: PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated.Results: Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p=0.000 for mutant homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p=0.000 for GG versus CC in the Arab descent.Conclusion: Our findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB.