RT Journal Article
SR Electronic
T1 The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1400
OP 1407
DO 10.15537/smj.2015.12.12264
VO 36
IS 12
A1 Lu, Hongfang
A1 Wang, Jingang
A1 Gao, Baoan
A1 Chen, Shixiong
A1 Xiang, Guangming
A1 Yang, Shaojuan
A1 Gong, Yuan
A1 Guan, Li
YR 2015
UL http://smj.org.sa/content/36/12/1400.abstract
AB Objectives: To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk.Methods: PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated.Results: Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p=0.000 for mutant homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p=0.000 for GG versus CC in the Arab descent.Conclusion: Our findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB.