RT Journal Article
SR Electronic
T1 Plasma homocysteine level in cardiac syndrome X and its relation with duke treadmill score
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 364
OP 367
VO 29
IS 3
A1 Timurkaynak, Timur
A1 Balcıoglu, Serhat
A1 Arslan, Ugur
A1 Kocaman, Sinan A.
A1 Cengel, Atiye
YR 2008
UL http://smj.org.sa/content/29/3/364.abstract
AB OBJECTIVE: To investigate the plasma homocysteine level and the relationship between plasma homocysteine level and duke treadmill score DTS in cardiac syndrome X CSX patients.METHODS: Seventy-nine patients 36 male, 43 female, mean age: 50 ± 8.8 years admitted to Gazi University Hospital, Ankara, Turkey with typical effort angina, positive stress test, and angiographically normal coronary arteries between January and September 2006 were included in this prospective and controlled study. Thirty asymptomatic patients 11 male, 19 female, mean age: 47.6 ± 8.3 years with 2 cardiovascular risk factors were chosen as a control group. Plasma homocysteine level was measured in both groups and DTS was calculated in the CSX group. Plasma homocysteine was measured with the AxSYM homocysteine immunoassay method in both groups.RESULTS: Plasma homocysteine level was higher in the CSX group compared to the control group 16.5 ± 4.9 μmol/L, n=79, versus 12.4 ± 4.1 μmol/L, n=30, p<0.001. The DTS was -2.7 ± 5.3 in the CSX group. There was a negative correlation between the DTS and homocysteine levels in the CSX group. r=-0.506, p<0.001.CONCLUSION: Plasma homocysteine level, which is known to cause endothelial dysfunction and microvascular ischemia were higher in CSX patients. Also, this increase in homocysteine level inversely correlated with the DTS, which represents the magnitude of ischemia.