PT  - JOURNAL ARTICLE
AU  - Al-Naami, Mohammed Y.
AU  - Guraya, Salman Y.
AU  - Arafah, Maha M.
AU  - Al-Zobydi, Abdu H.
AU  - Al-Tuwaijri, Talal A.
TI  - Clinicopathological pattern of malignant parotid gland tumors in Saudi Arabia
DP  - 2008 Mar 01
TA  - Saudi Medical Journal
PG  - 413--417
VI  - 29
IP  - 3
4099  - http://smj.org.sa/content/29/3/413.short
4100  - http://smj.org.sa/content/29/3/413.full
SO  - Saudi Med J2008 Mar 01; 29
AB  - OBJECTIVE: To report our experience of varied presentations and diverse histopathological spectrum of parotid gland malignancies.METHODS: This retrospective analysis incorporated patients with histological evidence of malignant parotid tumors at King Khalid University Hospital, Riyadh, Saudi Arabia over a 20-year period from 1984 through 2004. The medical records of these patients were analyzed for their demographic characteristics, clinical features, operations performed, and pathological diversity.RESULTS: Thirty-two patients comprised this study group. There is a male preponderance over females with a ratio of 2.2:1 22 men and 10 women and mean age of 51.8 range 28-81 years. A painless lump was the most frequent clinical manifestation observed in 23 71.8% patients followed by facial nerve dysfunction in 14 43.7% patients. Parotidectomy was performed in 22 68.7% patients: 16 superficial and 6 total. A partial facial nerve sacrifice was undertaken in 14 43.7%, and total nerve sacrifice in 9 28.1% patients. Four 12.5% patients presented with cervical lymph node metastases necessitating radical neck dissection. Nine 28.1% patients had mucoepidermoid carcinoma, 8 25% adenoid cystic carcinoma, 6 18.7% adenocarcinoma, not otherwise specified, and 2 6.2% were reported to have carcinoma in pleomorphic adenoma. Twenty 62.5% specimens revealed high-grade aggressive lesions, and out of these, 19 59.3% patients presented with stage III/IV disease.CONCLUSION: Malignant parotid tumors are exceedingly rare, occurring at a relatively earlier age group with male preponderance, and invariably declare at a late clinical stage in our community. Histopathological features hallmark a locally advanced disease with an aggressive behavior.