PT  - JOURNAL ARTICLE
AU  - Seyed V. Hosseini
AU  - Jalil Mohebzadeh
AU  - Perikala V. Kumar
AU  - Davood Mehrabani
AU  - Mohammad Bagheri
AU  - Seyed M. Sadjjadi
AU  - Masoud Amini
AU  - Afshin Amini
TI  - The effect of silver nitrate, chloroformic garlic extract, and normal saline in induction of sclerosing cholangitis in rabbits
DP  - 2008 Aug 01
TA  - Saudi Medical Journal
PG  - 1095--1098
VI  - 29
IP  - 8
4099  - http://smj.org.sa/content/29/8/1095.short
4100  - http://smj.org.sa/content/29/8/1095.full
SO  - Saudi Med J2008 Aug 01; 29
AB  - OBJECTIVE: To evaluate the effects of 0.5% silver nitrate, 20% chloroformic garlic extract, and 0.9% normal saline in induction of sclerosing cholangitis in the bile ducts of rabbits.METHODS: During a-6-months period from April to September 2006 in Shiraz University Laboratory Animal Research Center, we selected 3 equal groups of rabbits. We injected 0.5% silver nitrate, 20% chloroformic garlic extract, and 0.9% normal saline into the bile ducts of each group. The animals were euthanized, and autopsied after 4 months and the liver and bile ducts were removed and studied histopathologically. Cholangiography was undertaken to evaluate the presence and extent of any sclerosing cholangitis.RESULTS: Animals showed sclerosing cholangitis in silver nitrate group (7 [58%]), one (8%) in chloroformic garlic extract group and one (7%) in normal saline group. The difference between silver nitrate and chloroformic garlic extract groups were statistically significant and similar results were noticed between chloroformic garlic extract and normal saline groups.CONCLUSION: Twenty percent of chloroformic garlic extract had fewer complications such as sclerosing cholangitis, compared to other materials.