RT Journal Article
SR Electronic
T1 The effect of silver nitrate, chloroformic garlic extract, and normal saline in induction of sclerosing cholangitis in rabbits
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1095
OP 1098
VO 29
IS 8
A1 Seyed V. Hosseini
A1 Jalil Mohebzadeh
A1 Perikala V. Kumar
A1 Davood Mehrabani
A1 Mohammad Bagheri
A1 Seyed M. Sadjjadi
A1 Masoud Amini
A1 Afshin Amini
YR 2008
UL http://smj.org.sa/content/29/8/1095.abstract
AB OBJECTIVE: To evaluate the effects of 0.5% silver nitrate, 20% chloroformic garlic extract, and 0.9% normal saline in induction of sclerosing cholangitis in the bile ducts of rabbits.METHODS: During a-6-months period from April to September 2006 in Shiraz University Laboratory Animal Research Center, we selected 3 equal groups of rabbits. We injected 0.5% silver nitrate, 20% chloroformic garlic extract, and 0.9% normal saline into the bile ducts of each group. The animals were euthanized, and autopsied after 4 months and the liver and bile ducts were removed and studied histopathologically. Cholangiography was undertaken to evaluate the presence and extent of any sclerosing cholangitis.RESULTS: Animals showed sclerosing cholangitis in silver nitrate group (7 [58%]), one (8%) in chloroformic garlic extract group and one (7%) in normal saline group. The difference between silver nitrate and chloroformic garlic extract groups were statistically significant and similar results were noticed between chloroformic garlic extract and normal saline groups.CONCLUSION: Twenty percent of chloroformic garlic extract had fewer complications such as sclerosing cholangitis, compared to other materials.