PT  - JOURNAL ARTICLE
AU  - Yasir A. Bahadur
AU  - Camelia T. Constantinescu
AU  - Ashraf H. Hassouna
AU  - Mohamed E. El-Sayed
TI  - Treatment planning for high dose rate brachytherapy of cervical cancer based on total dose constraints.
DP  - 2011 May 01
TA  - Saudi Medical Journal
PG  - 495--503
VI  - 32
IP  - 5
4099  - http://smj.org.sa/content/32/5/495.short
4100  - http://smj.org.sa/content/32/5/495.full
SO  - Saudi Med J2011 May 01; 32
AB  - OBJECTIVES: To compare the inverse planning optimization based on total dose constraints versus conventional treatment plan (point A planning method) for cervical carcinoma, and evaluate the benefit of CT-based image-guided brachytherapy.METHODS: We prospectively analyzed data of 10 consecutive patients with cervical cancer treated with external beam radiotherapy to the whole pelvis (45 Gy in 25 fractions) followed by high-dose-rate (HDR) brachytherapy (21 Gy in 3 fractions). For treatment planning of HDR brachytherapy, the basic equations of the linear-quadratic model were used to calculate the physical dose for each brachytherapy fraction needed to achieve a given total iso-effective dose for the whole treatment. Specific dosimetric parameters are evaluated for high risk (HR CTV), intermediate risk (IR CTV) clinical target volumes, and organs at risk (OARs).RESULTS: In conventional plans, the HR CTV was well covered in only 15/31, and the IR CTV in 7/31 of the brachytherapy implants, while dose constraints of OARs bladder and rectum were respected in 28/31 and 14/31 implants. After optimization, the HR CTV and IR CTV dose constraints were respected in all the implants, and the bladder and rectum of cases dose constraints were respected in 25/31 and 17/31 of cases.CONCLUSIONS: Point A is a poor surrogate of target dose. Significant differences between point doses and dose volume histogram parameters indicate the need for inverse planning in image-guided brachytherapy of cervical cancer.