TY - JOUR T1 - Castleman's disease. Update on pathogenesis. JF - Saudi Medical Journal JO - Saudi Med J SP - 451 LP - 458 VL - 32 IS - 5 AU - Jaudah A. Al-Maghrabi Y1 - 2011/05/01 UR - http://smj.org.sa/content/32/5/451.abstract N2 - Castleman's disease (CD) is an unusual lymphoproliferative disorder that may mimic lymphoma clinically and pathologically. It is classified clinically as localized and multicentric types, and pathologically as hyaline vascular and plasma cell types. It is associated with increased risk of lymphoma and follicular dendritic cell tumors. The pathogenesis of CD is still controversial and complex. Active research is ongoing to highlight more on the etiopathogenesis of this entity. The aim of this article is to review the literature on pathogenesis of CD and to focus on the possible role of viruses in the development of this disease. ER -