PT  - JOURNAL ARTICLE
AU  - Ansar, Hasti
AU  - Mazloom, Zohreh
AU  - Kazemi, Fatemeh
AU  - Hejazi, Najmeh
TI  - Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.
DP  - 2011 Jun 01
TA  - Saudi Medical Journal
PG  - 584--588
VI  - 32
IP  - 6
4099  - http://smj.org.sa/content/32/6/584.short
4100  - http://smj.org.sa/content/32/6/584.full
SO  - Saudi Med J2011 Jun 01; 32
AB  - OBJECTIVES: To examine the effects of alpha-lipoic acid (ALA) treatment over a period of 2 months on fasting blood glucose (FBG), insulin resistance (IR), and glutathione peroxidase (GH-Px) activity in type 2 diabetes (T2DM) patients.METHODS: This study took place in Motahari Clinic, Shiraz, Iran, which is affiliated to Shiraz University of Medical Sciences from May to October 2006. Type 2 DM patients (n=57) were divided into 2 groups to receive either ALA (300 mg daily) or placebo by systematic randomization, and were followed-up for 8 weeks. After an overnight fasting and 2 hours after breakfast, patients' blood samples were drawn and tested for FBG, 2 hours PPG, serum insulin level, and GH-Px activity.RESULTS: The result of the study showed a significant decrease in FBG and PPG levels, IR-Homeostasis Model Assessment (IR-HOMA index) and GH-Px level in the ALA group. The comparison of differences between FBG and IR at the beginning and at the end of study in the ALA treated group and the placebo group were also significant.CONCLUSIONS: This study supports the use of ALA as an antioxidant in the care of diabetic patients.