PT  - JOURNAL ARTICLE
AU  - Arya, Subhash C.
AU  - Agarwal, Nirmala
TI  - Tigecycline in-vitro susceptibility and antibiotics' fitness for gram-negative pathogens
DP  - 2008 Nov 01
TA  - Saudi Medical Journal
PG  - 1558--1560
VI  - 29
IP  - 11
4099  - http://smj.org.sa/content/29/11/1558.short
4100  - http://smj.org.sa/content/29/11/1558.full
SO  - Saudi Med J2008 Nov 01; 29
AB  - OBJECTIVE: To determine the tigecycline in-vitro susceptibility of naive gram-negative pathogens from serious infections in Delhi, India.METHODS: During July to October 2007 investigations were carried out to determine the tigecycline in vitro susceptibility of 50 consecutive gram-negative pathogens from serious infections at the Sant Parmanand Hospital, Delhi, India. Minimum tigecycline inhibitory concentrations were determined employing the E test method (AB Biodisk).RESULTS: Twenty-four percent of isolates were found to be tigecycline resistant or partly susceptible. Susceptibility of the isolates was lower than meropenem but similar to piperacillin-tazobactam, amoxicillin-clavulanic acid, and amikacin.CONCLUSION: Tigecycline resistance was prevalent in the gram-negative isolates from serious infections prior to its marketing in India. The choice of any recently marketed antibiotic for a pilot treatment against serious gram-negative infections should not be automatic. In the initial phase of its marketing, it should be evaluated in parallel with the antibiotics with excellent local susceptibility profiles.