PT  - JOURNAL ARTICLE
AU  - Ozsoy, Umut
AU  - Mutluay, Ruya
AU  - Oygur, Nezih
AU  - Akbas, Halide
AU  - Sindel, Sukru
AU  - Sindel, Muzaffer
TI  - Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats
DP  - 2008 Nov 01
TA  - Saudi Medical Journal
PG  - 1561--1566
VI  - 29
IP  - 11
4099  - http://smj.org.sa/content/29/11/1561.short
4100  - http://smj.org.sa/content/29/11/1561.full
SO  - Saudi Med J2008 Nov 01; 29
AB  - OBJECTIVE: To evaluate the effect of renal denervation and serum nitric oxide level with a different time course of renal ischemia-reperfusion injury.METHODS: Thirty-six male Wistar rats were randomized into 6 groups. All rats underwent right nephrectomy to create a single kidney model. Renal denervated and innerved rats were subjected to renal clamping for 30-60 minutes. The study was performed in the Department of Anatomy, Akdeniz University, Antalya, Turkey, between June and November 2005.RESULTS: Combined effect of denervation and ischemia may caused significant increase in serum nitric oxide levels and decrease in glomerular filtration rates.CONCLUSION: Our results indicate that kidney denervation did not cause any changes in renal functions, but with ischemia it worsens the deleterious effect of ischemia-reperfusion injury, and causes a significant increase in serum nitric oxide levels.