PT  - JOURNAL ARTICLE
AU  - Haidari, Fatemeh
AU  - Seyed-Sadjadi, Neda
AU  - Taha-Jalali, Mohammad
AU  - Mohammed-Shahi, Majid
TI  - The effect of oral administration of Carum carvi on weight, serum glucose, and lipid profile in streptozotocin-induced diabetic rats.
DP  - 2011 Jul 01
TA  - Saudi Medical Journal
PG  - 695--700
VI  - 32
IP  - 7
4099  - http://smj.org.sa/content/32/7/695.short
4100  - http://smj.org.sa/content/32/7/695.full
SO  - Saudi Med J2011 Jul 01; 32
AB  - OBJECTIVES: To evaluate the effect of oral administration of caraway (Carum carvi) on the blood glucose level, lipid profile, and the weight of diabetic rats.METHODS: This investigation was carried out in Ahvaz University of Medical Sciences, Ahvaz, Iran between April and June 2010. Twenty-four male Wistar rats weighing 200-250 g were randomly divided into 3 groups: normal, diabetic, and caraway treated diabetic groups and were studied for 3 weeks. Diabetes was induced by intraperitoneal injection of 60 mg/kg body weight streptozotocin. Caraway was given orally at a dose of 1g/kg body weight daily, and the body weight of animals was measured every day. Blood samples were collected and blood glucose levels and lipid profile were determined.RESULTS: The results showed that oral administration of caraway caused a significant decrease in blood glucose level of treated rats (p = 0.001) and alleviated their body weight loss (p = 0.037). Furthermore, it caused significant decrease in total cholesterol (p = 0.036), and low-density lipoprotein cholesterol levels (p = 0.001) in the treated animals compared with the diabetic control rats, and with no significant change in triglyceride and high-density lipoprotein cholesterol levels.CONCLUSIONS: Caraway has both antihyperglycemic and hypolipidemic activity in diabetic rats. Nevertheless, it is not recommended before further investigations in animals and humans.