PT  - JOURNAL ARTICLE
AU  - Alameri, Hatem F.
AU  - Aleem, Aamer
AU  - Kardas, Walid
AU  - Jehangir, Ahmed
AU  - Owais, Mohammad
AU  - Al-Momen, Abdulkarim
TI  - Dyspnea, pulmonary function and exercise capacity in adult Saudi patients with sickle cell disease
DP  - 2008 May 01
TA  - Saudi Medical Journal
PG  - 707--713
VI  - 29
IP  - 5
4099  - http://smj.org.sa/content/29/5/707.short
4100  - http://smj.org.sa/content/29/5/707.full
SO  - Saudi Med J2008 May 01; 29
AB  - OBJECTIVE: To examine pulmonary function, dyspnea and exercise capacity in adult Saudi sickle cell disease SCD patients.METHODS: The patients were recruited from the hematology clinic at King Khalid University Hospital in Riyadh from January to December 2005. The study involved 39 patients with stable SCD 20 women and 19 men, with a mean age of 22.7±7.1 years, hemoglobin level of 95.5±14.6 g/L and hemoglobin F level of 13.7±8.6%. Patients underwent pulmonary function tests PFT forced expiratory volume in first second [FEV1], forced vital capacity [FVC], and diffusion capacity of carbon monoxide [DLco] data are presented as a percentage of the normal prediction, a 6-minute walk test 6MWT and echocardiography. Dyspnea was assessed using the Borg score. The 6MWT data were compared to body mass index-matched healthy controls.RESULTS: Forty-one percent of SCD patients had mild dyspnea at rest, and this increased to 61% at the end of the 6MWT. Pulmonary function tests were abnormal in 51% 36% of patients had a restrictive pattern, 10% had isolated decrease in DLco, and 5% had a mixed restrictive-obstructive pattern. The 6MWD was shorter in SCD patients compared to the controls 368±67 versus 407±47m, p=0.005. No hematological variables correlated with outcome variables.CONCLUSION: Chronic pulmonary complications in adult Saudi SCD patients are relatively mild but common. Pulmonary function in these patients differs from that published for African-origin SCD patients. This difference may reflect a different natural history of SCD in the 2 populations.