RT Journal Article
SR Electronic
T1 The effect of paclitaxel on rats following benzoapyrene treatment
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 657
OP 661
VO 29
IS 5
A1 Cosan, Didem
A1 Basaran, Ayse
A1 Degirmenci, Irfan
A1 Gunes, Hasan V.
A1 Aral, Erinc
YR 2008
UL http://smj.org.sa/content/29/5/657.abstract
AB OBJECTIVE: To observe the effects of paclitaxel on rats that received benzoapyrene.METHODS: In this study, 45 male Sprague-Dawley rats aged 2-month-old were used, which were housed at the Medical Biology Department of Eskisehir Osmangazi University, Eskisehir, Turkey in 2006. Urine, blood, liver, and kidney tissue samples of Sprague Dawley rats treated with benzoapyrene and paclitaxel were examined in our study. Biochemical data were evaluated on urine and blood samples, and liver and kidney tissue samples were investigated by light microscopy.RESULTS: Superoxide dismutase, catalase activities, and malondialdehyde values in the group which received benzoapyrene were significantly different than the control, and most of these parameters came close to control values in the group that received paclitaxel following benzoapyrene application. Histological appearances of the samples of all rats also supported the biochemical results.CONCLUSION: The present study indicated that liver and kidney structures damaged by benzoapyrene may be restored by paclitaxel.