RT Journal Article
SR Electronic
T1 An investigation on lung tissue damage and morphological changes in newborns of pregnant rats exposed to methidathion. Protective effects of caffeic acid phenethyl ester
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1095
OP 1100
VO 31
IS 10
A1 Sulak, Osman
A1 Ozguner, Gulnur
A1 Sahin, Onder
A1 Bas, Orhan
YR 2010
UL http://smj.org.sa/content/31/10/1095.abstract
AB OBJECTIVE: To investigate histopathological changes in the lungs and morphological changes of newborn rats whose mothers are exposed to methidathion (MD) during their pregnancy, and also the effects of caffeic acid phenethyl ester (CAPE) on these changes.METHODS: The study was conducted in the Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey between May and June 2007. Fifty female Wistar albino rats were randomly divided into 5 groups, as follows: Group I (n=10): control group, Group II (n=10): 5mg/kg/day MD treated group in the first 7 days of pregnancy, Group III (n=10): 5 mg/kg/day MD + 10 umol/kg/day CAPE treated group in the first 7 days of pregnancy, Group IV (n=10): 5mg/kg/day MD treated group in the last 7 days of pregnancy, and Group V (n=10): 5 mg/kg/day MD + 10 umol/kg/day CAPE treated group in the last 7 days of pregnancy. The MD was administrated by oral gavage in corn oil, and the CAPE was administrated intraperitoneally.RESULTS: Tremors, agitation, and spasm of extremities were observed in pregnant rats after administration of MD. Histopathological examination of lung tissues revealed peribronchial inflammation, alveolar and bronchoalveolar hemorrhage, intraparenchymal vascular congestion and thrombosis, alveolar destruction, and intraparenchymal infiltration.CONCLUSION: Methidathion causes low weight gain and deaths among pregnant rats, increases intrauterine fetus deaths, causes low birth weights in the newborns, and histopathological changes in the lung tissues of newborn rats. The CAPE has an ameliorating effect on these histopathological alterations.