RT Journal Article
SR Electronic
T1 Effects of telmisartan on insulin resistance and visceral fat distribution in Chinese hypertensive patients with obesity.
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1017
OP 1021
VO 32
IS 10
A1 Gao-Zhong Huang
A1 Ye-Hua Tang
A1 Bei-Yun Wang
A1 Bei Zhang
A1 Ting-Jun Hu
A1 Li Zhang
A1 Xiao-Yan Zhang
A1 Yuan Zhong
YR 2011
UL http://smj.org.sa/content/32/10/1017.abstract
AB OBJECTIVES: To investigate the effects of telmisartan on body fat distribution and insulin sensitivity in patients with hypertension and obesity.METHODS: In this prospective, randomized study, outpatients from the Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China were treated with telmisartan (n=23), or losartan (n=22) for 16 weeks between December 2009 to January 2011. Parameters such as waist and hip circumference, body mass index, fasting blood glucose, insulin, lipids, serum adiponectin, and tumor necrosis factor-alpha (TNF-alpha) were measured before and after treatment. The abdominal visceral fat area (VFA) and subcutaneous fat area (SFA) were determined by magnetic resonance imaging. Insulin sensitivity was estimated by homeostasis model assessment (HOMA-IR).RESULTS: Compared with baseline, the systolic and diastolic blood pressure decreased significantly in both groups. However, the levels of HOMA-IR, serum adiponectin, and TNF-alpha only improved in the telmisartan group. Similarly, the VFA was reduced in the telmisartan group, while the SFA did not change in either group.CONCLUSIONS: Telmisartan improves both hemodynamic and metabolic abnormalities found in hypertensive patients with obesity. The additional benefits may be partly due to visceral fat remodeling.