PT  - JOURNAL ARTICLE
AU  - Khasawneh, Faisal A.
AU  - Ashcraft, Deborah S.
AU  - Pankey, George A.
TI  - In vitro testing of daptomycin plus rifampin against methicillin-resistant Staphylococcus aureus resistant to rifampin
DP  - 2008 Dec 01
TA  - Saudi Medical Journal
PG  - 1726--1729
VI  - 29
IP  - 12
4099  - http://smj.org.sa/content/29/12/1726.short
4100  - http://smj.org.sa/content/29/12/1726.full
SO  - Saudi Med J2008 Dec 01; 29
AB  - OBJECTIVE: To test for synergy between daptomycin (DAP) and rifampin (RIF) against RIF-resistant methicillin-resistant Staphylococcus aureus (MRSA) isolates.METHODS: Synergy testing using time-kill assay (TKA) was performed on 6 clinically, and genetically unique RIF-resistant MRSA isolates. The isolates were identified out of 489 (1.2%) samples collected during April 2003 to August 2006, from patients at the Ochsner Medical Center in New Orleans, Louisiana, United States of America.RESULTS: Synergy testing of DAP plus RIF by TKA showed that 5 isolates were indifferent, but one isolate was antagonistic.CONCLUSION: Our in vitro study failed to demonstrate synergy between DAP plus RIF, against our RIF-resistant MRSA isolates. Clinical failure of this combination should prompt the clinician to consider antagonism, as one of the potential causes.