RT Journal Article
SR Electronic
T1 In vitro testing of daptomycin plus rifampin against methicillin-resistant Staphylococcus aureus resistant to rifampin
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1726
OP 1729
VO 29
IS 12
A1 Khasawneh, Faisal A.
A1 Ashcraft, Deborah S.
A1 Pankey, George A.
YR 2008
UL http://smj.org.sa/content/29/12/1726.abstract
AB OBJECTIVE: To test for synergy between daptomycin (DAP) and rifampin (RIF) against RIF-resistant methicillin-resistant Staphylococcus aureus (MRSA) isolates.METHODS: Synergy testing using time-kill assay (TKA) was performed on 6 clinically, and genetically unique RIF-resistant MRSA isolates. The isolates were identified out of 489 (1.2%) samples collected during April 2003 to August 2006, from patients at the Ochsner Medical Center in New Orleans, Louisiana, United States of America.RESULTS: Synergy testing of DAP plus RIF by TKA showed that 5 isolates were indifferent, but one isolate was antagonistic.CONCLUSION: Our in vitro study failed to demonstrate synergy between DAP plus RIF, against our RIF-resistant MRSA isolates. Clinical failure of this combination should prompt the clinician to consider antagonism, as one of the potential causes.