RT Journal Article
SR Electronic
T1 The effects of N-acetylcysteine on intestinal ischemia/reperfusion injury in rats
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 24
OP 29
VO 30
IS 1
A1 Ayvaz, Suleyman
A1 Aksu, Burhan
A1 Inan, Mustafa
A1 Uzun, Hafize
A1 Aydin, Seval
A1 Bilgi, Selcuk
A1 Umit, Hasan C.
A1 Pul, Mehmet
YR 2009
UL http://smj.org.sa/content/30/1/24.abstract
AB OBJECTIVE: To evaluate the effects of N-acetylcysteine NAC on the injury of intestinal ischemia-reperfusion.METHODS: Forty-eight Wistar-Albino rats were divided into 6 groups: as control, ischemia, ischemia-reperfusion, ischemia + N-acetylcysteine, ischemia-reperfusion + N-acetylcysteine IRN, and reperfusion + N-acetylcysteine RN. Histopathologic examination was performed to all groups. In the tissue and plasma, and erythrocyte samples, malondialdehyde, superoxide dismutase, glutathione, and nitric oxide NO levels were evaluated. The present study was carried out in Trakya and Istanbul University, Edirne, Turkey between December 2002 and July 2003.RESULTS: The most severe histopathological damage was seen in the intestinal ischemia-reperfusion group, and this damage was observed to be reduced by NAC administration. Lowest plasma malondialdehyde levels were observed in RN group. The tissue glutathione levels were found to be higher in RN group than those in IRN group.CONCLUSION: It was found that administration of NAC has important effects on the injury of intestinal ischemia, as well as, reperfusion in rats. N-acetylcysteine administration causes an improvement in the histopathologic findings of ischemia/reperfusion damages. The N-acetylcysteine treatment protects the antioxidant enzymes in the tissue, plasma, and the erythrocytes, which are crucially important in the intestinal schemia/reperfusion injury in rats.