RT Journal Article
SR Electronic
T1 Gene and environment interaction in familial suicidal behavior. A single family with 4 committed suicides.
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1073
OP 1077
VO 32
IS 10
A1 Khazaie, Habibolah
A1 Rezaie, Leeba
A1 Alibakhshi, Reza
A1 Schwebel, David C.
YR 2011
UL http://smj.org.sa/content/32/10/1073.abstract
AB Family history of suicide is among the strongest predictors of suicide risk. From the context of gene by environment interactions, this manuscript presents a case study of the M family, which experienced 4 committed suicides within a short time period. Over the course of 5 years, the father and 3 sons committed suicide. Suicidal ideations developed in several other members of the family. The family's suicide risk appears to have stemmed from both environmental and genetic factors, and likely from an interactive effect between both. Environmental factors included low level of education, opium dependency among male family members, unemployment, and poverty, and limited access to mental health services. Genotype analyses of A218C polymorphism among surviving family members revealed that all individuals were associated with the gene variation genotypes CC and AC in tryptophan hydroxylase. The genetic by environmental interaction influence is discussed.