PT  - JOURNAL ARTICLE
AU  - Senturk, Tunay
AU  - Sarandol, Emre
AU  - Gullulu, Sumeyye
AU  - Erdinc, Selda
AU  - Ozdabakoglu, Osman
AU  - Ozdemir, Bulent
AU  - Baran, Ibrahim
AU  - Arslan, Sinan
AU  - Aydinlar, Ali
TI  - Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes
DP  - 2009 Mar 01
TA  - Saudi Medical Journal
PG  - 334--339
VI  - 30
IP  - 3
4099  - http://smj.org.sa/content/30/3/334.short
4100  - http://smj.org.sa/content/30/3/334.full
SO  - Saudi Med J2009 Mar 01; 30
AB  - OBJECTIVE: To examined whether serum paraoxonase (PON1) and arylesterase (ARE) activities are correlated with inflammatory biomarkers (procalcitonin and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS).METHODS: This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turkey, from April 2007 to December 2007. Seventy-eight consecutive patients with ACS and 39 healthy controls were investigated. Acute coronary syndrome patients were divided into 3 groups according to their clinical presentation: unstable angina pectoris (UAP) (Braunwald III-B, n=25), non-ST elevation myocardial infarction (NSTEMI) (n=18), and ST-elevation myocardial infarction (STEMI) (n=35). Serum PON1/ARE activities were measured spectrophotometrically. Levels of procalcitonin and hs-CRP were measured by immunoassay.RESULTS: Paraoxonase/ARE activities were significantly lower in all patient groups compared to controls. No correlation between PON1/ARE activities and high-density-cholesterol levels was seen. Among ACS patients, serum ARE activity correlated inversely with baseline and 48-hour procalcitonin (r=-0.577, p=0.009, and r=-0.642, p=0.019) and hs-CRP levels (r=-0.614, p=0.03, and r=-0.719, p=0.044).CONCLUSION: Serum ARE activity is reduced in ACS patients and inversely correlated with inflammatory markers.