PT  - JOURNAL ARTICLE
AU  - Bakhamees, Hassan S.
AU  - Mercan, Arzu
AU  - El-Halafawy, Yasser M.
TI  - Combination effect of low dose fentanyl and propofol on emergence agitation in children following sevoflurane anesthesia
DP  - 2009 Apr 01
TA  - Saudi Medical Journal
PG  - 500--503
VI  - 30
IP  - 4
4099  - http://smj.org.sa/content/30/4/500.short
4100  - http://smj.org.sa/content/30/4/500.full
SO  - Saudi Med J2009 Apr 01; 30
AB  - OBJECTIVE: To investigate the combination effect of low dose fentanyl and subhypnotic dose of propofol on emergence agitation in children receiving sevoflurane for adenotonsillectomy procedure.METHODS: After ethical approval, a prospective, randomized, clinical study was performed in Saad Specialist Hospital, Al-Khobar, Kingdom of Saudi Arabia in 2007-2008. One hundred and twenty children in physical status of I according to the American Society of Anesthesiologists, aged 2-6 years, scheduled for adentonsillectomy under general anesthesia were allocated into 3 groups randomly. Anesthesia was induced and maintained by sevoflurane in all groups. Children received 0.1 ml.kg-1 normal saline at the end of surgery in group C (n=40), 1.5 mcg.kg-1 fentanyl during induction, and 0.1 ml.kg-1 normal saline at the end of surgery in group F (n=40), and 1.5 mcg.kg-1 fentanyl during induction and 1 mg.kg-1 propofol at the end of surgery in group FP (n=40). Postoperative agitation was recorded, if any, for the first postoperative hour.RESULTS: Three groups were comparable with regard to demographic data. Twenty-one patients (53%) in the control group, 14 patients (35%) in group F and 7 (18%) patients in group FP experienced postoperative agitation.CONCLUSION: The combination of low dose fentanyl before surgery and propofol at the end of surgery decreases the incidence and level of emergence agitation in children after adenotonsillectomy procedure under sevoflurane anesthesia.