PT  - JOURNAL ARTICLE
AU  - Gazzaz, Faten S.
AU  - Mosli, Hisham A.
TI  - Lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies
DP  - 2009 May 01
TA  - Saudi Medical Journal
PG  - 633--637
VI  - 30
IP  - 5
4099  - http://smj.org.sa/content/30/5/633.short
4100  - http://smj.org.sa/content/30/5/633.full
SO  - Saudi Med J2009 May 01; 30
AB  - OBJECTIVE: To explore the possibility of finding human papillomavirus (HPV) infection in the prostate tissue of a cohort of Saudi men presenting with benign prostatic hyperplasia (BPH) or prostate cancer.METHODS: A cohort study on prospectively collected tissue samples was conducted at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia from March 2007 to December 2008 on a total of 56 male patients, age range 50-93 years (average 68), diagnosed as having BPH or prostate cancer. The HPV DNA hybridization by hybrid capture 2 technology was performed on prostate biopsies of these patients to detect 18 types of HPV infection, and differentiate between 2 HPV DNA groups, the low-risk types, and the high/intermediate risk types.RESULTS: The tissues of all the prostatic biopsies were negative for HPV DNA.CONCLUSION: Our results, using the hybridization test, indicate that it is unlikely that HPV-16 or HPV-18, or the other tested subtypes, enhance the risk of prostate cancer.