RT Journal Article
SR Electronic
T1 Lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 633
OP 637
VO 30
IS 5
A1 Gazzaz, Faten S.
A1 Mosli, Hisham A.
YR 2009
UL http://smj.org.sa/content/30/5/633.abstract
AB OBJECTIVE: To explore the possibility of finding human papillomavirus (HPV) infection in the prostate tissue of a cohort of Saudi men presenting with benign prostatic hyperplasia (BPH) or prostate cancer.METHODS: A cohort study on prospectively collected tissue samples was conducted at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia from March 2007 to December 2008 on a total of 56 male patients, age range 50-93 years (average 68), diagnosed as having BPH or prostate cancer. The HPV DNA hybridization by hybrid capture 2 technology was performed on prostate biopsies of these patients to detect 18 types of HPV infection, and differentiate between 2 HPV DNA groups, the low-risk types, and the high/intermediate risk types.RESULTS: The tissues of all the prostatic biopsies were negative for HPV DNA.CONCLUSION: Our results, using the hybridization test, indicate that it is unlikely that HPV-16 or HPV-18, or the other tested subtypes, enhance the risk of prostate cancer.