PT  - JOURNAL ARTICLE
AU  - Yusuf Unal
AU  - Ozgur Ozsoylar
AU  - Mustafa Arslan
AU  - Damla Sariguney
AU  - Mehmet Akcabay
TI  - Comparison of the efficacy of propofol and metoclopramide in preventing postoperative nausea and vomiting after middle ear surgery
DP  - 2009 Jun 01
TA  - Saudi Medical Journal
PG  - 778--782
VI  - 30
IP  - 6
4099  - http://smj.org.sa/content/30/6/778.short
4100  - http://smj.org.sa/content/30/6/778.full
SO  - Saudi Med J2009 Jun 01; 30
AB  - OBJECTIVE: To compare the administration of sub hypnotic dose of propofol with metoclopramide and placebo in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery.METHODS: This clinical research was performed in the Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey, between December 2004 and October 2005. Following approval by the hospital ethics committee, 60 adult patients scheduled for a middle ear operation were randomly assigned into 3 groups. The patients in group P received 0.5 mg.kg-1 propofol; in group M, 0.2 mg.kg-1 metoclopramide, and in group C, 0.9% saline solution. The number of patients suffering from nausea and vomiting at 0-4, 4-12, and 12-24 hours postoperatively, and additional use of antiemetics was recorded.RESULTS: Comparisons of the data showed that at 0-4th hours, the incidence of vomiting was 25% in group P, 40% in group M, and 75% in group C. The incidence rate of group P was significantly lower than that of group C (p=0.002), and the rate of antiemetics use in group C was higher than that in group P (p=0.028). The Nausea Vomiting Scale scores of group C were also significantly higher than those of group P (p=0.005). There were no significant differences between the values at 4-12 and 12-24 hours.CONCLUSION: The administration of a sub hypnotic dose of propofol at the end of surgery was found to be at least as effective as metoclopramide in preventing PONV in the early postoperative period in adult patients undergoing middle ear surgery. The administration of a sub hypnotic dose of propofol at the end of surgery was found to be at least as effective as metoclopramide in preventing PONV in the early postoperative period in adult patients undergoing middle ear surgery.