RT Journal Article
SR Electronic
T1 Lung cancer stem cells research. Clues from ontogeny
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1381
OP 1389
VO 30
IS 11
A1 Yu Xu
A1 Yi-De Hu
YR 2009
UL http://smj.org.sa/content/30/11/1381.abstract
AB Cancer stem cell (CSC) hypothesis provides us with a new approach to the understanding of carcinogenesis, therapeutics, and prevention strategies. In recent years, the origin and biological characteristics of CSC were widely studied in solid tumors; it is astonishing to find out the delicate relevancy between CSC and committed progenitors evolved from embryonic stem cells (ESC) during organ development. In this review, we propose that some key molecular signal pathways during lung development are crucial for abnormal self-renewal and differentiation of lung cancer stem cell as well as try to elaborate the lung CSCs from the point view of ontogeny.