PT  - JOURNAL ARTICLE
AU  - Kuzhan, Okan
AU  - Ozet, Ahmet
AU  - Ulutin, Cuneyt
AU  - Kurt, Bulent
AU  - Komurcu, Seref
AU  - Ozturk, Bekir
AU  - Ataergin, Selmin
AU  - Gunhan, Omer
TI  - Impact of c-erb2 status on survival after high dose chemotherapy in high-risk breast cancer patients
DP  - 2007 Sep 01
TA  - Saudi Medical Journal
PG  - 1374--1379
VI  - 28
IP  - 9
4099  - http://smj.org.sa/content/28/9/1374.short
4100  - http://smj.org.sa/content/28/9/1374.full
SO  - Saudi Med J2007 Sep 01; 28
AB  - OBJECTIVE: To investigate the impact of c-erb2 status on survival after high-dose chemotherapy.METHODS: Between March 1997 and June 2004, a total of 54 women with breast cancer who has at least 8 metastatic lymph nodes underwent high-dose chemotherapy with hematopoietic stem cell transplantation in Gulhane Military Medical School, Ankara, Turkey. Archival specimens were analyzed by fluorescent in situ hybridization to determine the impact of c-erb2 status after peripheral blood stem cell transplantation on survival. The patients were divided into c-erb2 negative (n=20) and positive (n=11) groups.RESULTS: No statistically significant differences were detected between c-erb2 negative and positive groups regarding 5-year disease-free survival (41 and 27%, log rank p=0.11), and overall survival (60 and 45%, p=0.33). Transplant related mortality did not differ between groups.CONCLUSION: We found no differences between c-erb2 negative and positive groups regarding disease-free and overall survival. To clarify the value of the c-erb2 status in predicting outcome after high-dose chemotherapy, prospective randomized studies are needed.